Gabai Andrea, Zeppieri Marco, Finocchio Lucia, Salati Carlo
Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
Department of Ophthalmology, Nuovo Ospedale Santo Stefano, 59100 Prato, Italy.
Pharmaceutics. 2023 Jul 1;15(7):1862. doi: 10.3390/pharmaceutics15071862.
Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel matrices, and non-traditional treatment strategies, open new perspectives in this field. The aim of this mini-review is to highlight promising strategies reported in the current literature based on innovative routes to overcome the anatomical and physiological barriers of the vitreoretinal structures. The paper also describes the challenges in finding appropriate and pertinent treatments that provide safety and efficacy and the problems related to patient compliance, acceptability, effectiveness, and sustained drug delivery. The clinical application of these experimental approaches can help pave the way for standardizing the use of DDSs in developing enhanced treatment strategies and personalized therapeutic options for ocular pathologies.
近年来，创新型和新型药物递送系统（DDS）已被开发出来，用于将治疗方法和药物输送到眼后段和视网膜。新的制剂和技术发展，如纳米技术、新型基质和非传统治疗策略，为该领域开辟了新的前景。本综述的目的是强调当前文献中报道的基于创新途径的有前景的策略，以克服玻璃体视网膜结构的解剖学和生理学障碍。本文还描述了寻找提供安全性和有效性的合适且相关治疗方法所面临的挑战，以及与患者依从性、可接受性、有效性和持续药物递送相关的问题。这些实验方法的临床应用有助于为在开发增强治疗策略和针对眼部疾病的个性化治疗选择中规范DDS的使用铺平道路。
