Yorsaeng Ritthideach, Atsawawaranunt Kamolthip, Suntronwong Nungruthai, Kanokudom Sitthichai, Chansaenroj Jira, Assawakosri Suvichada, Nilyanimit Pornjarim, Aeemjinda Ratchadawan, Khanarat Nongkanok, Wongsrisang Lakkhana, Auphimai Chompoonut, Vichaiwattana Preeyaporn, Klinfueng Sirapa, Thongmee Thanunrat, Srimuan Donchida, Thatsanathorn Thaksaporn, Sudhinaraset Natthinee, Wanlapakorn Nasamon, Poovorawan Yong
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Pathum Wan, Bangkok 10330, Thailand.
Institute for Urban Disease Control and Prevention, Department of Disease Control, Ministry of Public Health, Anusawari, Bang Khen, Bangkok 10220, Thailand.
Vaccines (Basel). 2023 Jun 30;11(7):1184. doi: 10.3390/vaccines11071184.
The Coronavirus disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), continues to surge despite the widespread use of vaccination. In Thailand, more than 77% and 39% of the population received two doses and three doses of COVID-19 vaccines as of December 2022, respectively. In addition, during the Omicron predominant period in 2022, more than 70% of Thai individuals have been infected. To gain comprehensive insight into SARS-CoV-2 antibody dynamics following vaccination or following vaccination and infection (hybrid immunity), we performed a cross-sectional analysis of sera samples from individuals who received COVID-19 vaccination and/or have been infected with COVID-19 in Thailand between January 2021 and December 2022. A total of 4126 samples were collected. Humoral immunity was evaluated by quantifying the immunoglobulin (including IgG, IgM, and IgA isotypes) specific to the SARS-CoV-2 receptor-binding domain (RBD) or Ig anti-RBD. The results showed that individuals who received two-dose vaccination alone had lower levels of Ig anti-RBD, which rapidly waned over time. To restore the waning antibody, a third dose vaccination is recommended for uninfected individuals who have only received 2 doses.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行，尽管疫苗已广泛使用，但仍在激增。在泰国，截至2022年12月，分别有超过77%和39%的人口接种了两剂和三剂COVID-19疫苗。此外，在2022年奥密克戎毒株占主导的时期，超过70%的泰国人受到了感染。为了全面了解接种疫苗后或接种疫苗并感染（混合免疫）后的SARS-CoV-2抗体动态，我们对2021年1月至2022年12月期间在泰国接种了COVID-19疫苗和/或感染了COVID-19的个体的血清样本进行了横断面分析。总共收集了4126份样本。通过定量针对SARS-CoV-2受体结合域（RBD）的免疫球蛋白（包括IgG、IgM和IgA亚型）或抗RBD Ig来评估体液免疫。结果显示，仅接种两剂疫苗的个体抗RBD Ig水平较低，且随时间迅速下降。为了恢复逐渐减少的抗体，建议仅接种了两剂疫苗的未感染个体接种第三剂疫苗。
