Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tokyo 321-3497, Japan.
Sensory Science Research, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan.
Viruses. 2023 Jun 23;15(7):1421. doi: 10.3390/v15071421.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious and continues to spread worldwide. To avoid the spread of infection, it is important to control its transmission routes. However, as methods to prevent airborne infections are lacking, people are forced to take measures such as keeping distance from others or wearing masks. Here, we evaluate the antiviral activity of propylene glycol (PG), which is safe, odorless, and volatile. PG showed pronounced antiviral activity against the influenza virus (IAV) at concentrations above 55% in the liquid phase. Given its IAV inactivation mechanism, which involves increasing the fluidity of the viral membrane, PG is expected to have a broad effect on enveloped viruses. PG showed antiviral activity against SARS-CoV-2. We also developed a system to evaluate the antiviral effect of PG in spray and volatilized forms. PG was found to be effective against aerosol IAV in both forms; the effective PG concentration against IAV in the vapor phase was 87 ppmv (0.27 mg/L). These results demonstrate that PG is an effective means for viral inactivation in various situations for infection control. This technology is expected to control the spread of current and future infectious diseases capable of causing outbreaks and pandemics.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）具有很强的传染性，并且在全球范围内继续传播。为了避免感染的传播，控制其传播途径很重要。然而，由于缺乏预防空气传播感染的方法，人们被迫采取保持距离或戴口罩等措施。在这里，我们评估了丙二醇（PG）的抗病毒活性，PG 安全、无味、易挥发。PG 在液相中浓度高于 55%时，对流感病毒（IAV）表现出明显的抗病毒活性。鉴于其 IAV 失活动力学，涉及增加病毒膜的流动性，PG 有望对包膜病毒产生广泛的影响。PG 对 SARS-CoV-2 表现出抗病毒活性。我们还开发了一种评估 PG 喷雾和挥发形式抗病毒效果的系统。PG 在这两种形式下均对气溶胶 IAV 有效；气相中对 IAV 有效的 PG 浓度为 87ppmv（0.27mg/L）。这些结果表明 PG 是控制感染控制各种情况下病毒失活的有效手段。这项技术有望控制当前和未来能够引发爆发和大流行的传染病的传播。
