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具有抗甲型流感病毒/WS/33活性的香精油化学成分。

Chemical Constituents of Essential Oils Possessing Anti-Influenza A/WS/33 Virus Activity.

作者信息

Choi Hwa-Jung

机构信息

Department of Beauty Science, Kwangju Women's University, Gwangju, Korea.

出版信息

Osong Public Health Res Perspect. 2018 Dec;9(6):348-353. doi: 10.24171/j.phrp.2018.9.6.09.

DOI:10.24171/j.phrp.2018.9.6.09
PMID:30584499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6296812/
Abstract

OBJECTIVES

This study was conducted to determine whether essential oils had anti-influenza A/WS/33 virus activity and whether there were specific compounds associated with this activity.

METHODS

There were 63 essential oils evaluated for anti-influenza (A/WS/33 virus) activity using a cytopathic effect reduction method. The chemical composition of the anti-influenza essential oils was phytochemically analyzed by gas chromatography-mass spectrometry.

RESULTS

The antiviral assays demonstrated that 11 of the 62 essential oils (100 μg/mL) possessed anti-influenza activity, reducing visible cytopathic effects of influenza A/WS/33 virus activity by > 30%. Furthermore, marjoram, clary sage and anise oils exhibited anti-influenza A/WS/33 virus activity of > 52.8%. However, oseltamivir (the anti-influenza A and B drug), showed cytotoxicity at the same concentration (100 μg/mL) as the essential oils. The chemical composition detected by GC-MS analysis, differed amongst the 3 most potent anti-viral essential oils (marjoram, clary sage and anise oils) except for linalool, which was detected in all 3 essential oils.

CONCLUSION

This study demonstrated anti-influenza activity in 11 essential oils tested, with marjoram, clary sage and anise essential oils being the most effective at reducing visible cytopathic effects of the A/WS/33 virus. All 3 oils contained linalool, suggesting that this may have anti-influenza activity. Further investigation is needed to characterize the antiviral activity of linalool against influenza A/WS/33 virus.

摘要

目的

本研究旨在确定香精油是否具有抗甲型流感病毒/WS/33活性，以及是否存在与该活性相关的特定化合物。

方法

采用细胞病变效应降低法对63种香精油进行抗流感（甲型流感病毒/WS/33）活性评估。利用气相色谱 - 质谱联用技术对具有抗流感活性的香精油进行植物化学分析，以确定其化学成分。

结果

抗病毒试验表明，62种香精油中的11种（100μg/mL）具有抗流感活性，可使甲型流感病毒/WS/33的可见细胞病变效应降低超过30%。此外，马郁兰、鼠尾草和茴芹油表现出超过52.8%的抗甲型流感病毒/WS/33活性。然而，在与香精油相同浓度（100μg/mL）下，抗甲型和乙型流感药物奥司他韦显示出细胞毒性。气相色谱 - 质谱联用分析检测到这3种最有效的抗病毒香精油（马郁兰、鼠尾草和茴芹油）的化学成分存在差异，但所有3种香精油中均检测到芳樟醇。

结论

本研究证明，在所测试的11种香精油中具有抗流感活性，其中马郁兰、鼠尾草和茴芹香精油在降低甲型流感病毒/WS/33可见细胞病变效应方面最为有效。所有3种油均含有芳樟醇，表明其可能具有抗流感活性。需要进一步研究以确定芳樟醇对甲型流感病毒/WS/33的抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0457/6296812/6ccaa93e7ebe/ophrp-09-348f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0457/6296812/4d6f191c2289/ophrp-09-348f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0457/6296812/6ccaa93e7ebe/ophrp-09-348f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0457/6296812/4d6f191c2289/ophrp-09-348f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0457/6296812/6ccaa93e7ebe/ophrp-09-348f2.jpg

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