Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.
Viruses. 2023 Jul 11;15(7):1530. doi: 10.3390/v15071530.
Hepatitis delta virus (HDV) is the smallest known human virus and causes the most severe form of human viral hepatitis, yet it is still not fully understood how the virus replicates and how it interacts with many host proteins during replication. This review aims to provide a systematic review of all the host factors currently known to interact with HDV and their mechanistic involvement in all steps of the HDV replication cycle. Finally, we discuss implications for therapeutic development based on our current knowledge of HDV-host protein interactions.
乙型肝炎 delta 病毒（HDV）是已知最小的人类病毒，可引起最严重的人类病毒性肝炎，但人们对其复制方式以及在复制过程中与许多宿主蛋白相互作用的方式仍不完全了解。本文旨在对目前已知与 HDV 相互作用的所有宿主因子进行系统综述，并探讨它们在 HDV 复制周期各个步骤中的作用机制。最后，我们根据目前对 HDV-宿主蛋白相互作用的了解，讨论基于该机制的治疗开发的意义。
