Laboratório de Campanha para Testagem e Pesquisa do COVID-19 (LCC), Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Macaé 27965-045, RJ, Brazil.
Laboratório de Virologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil.
Viruses. 2023 Jul 13;15(7):1545. doi: 10.3390/v15071545.
COVID-19 has infected humans worldwide, causing millions of deaths or prolonged symptoms in survivors. The transient or persistent symptoms after SARS-CoV-2 infection have been defined as post-COVID-19 conditions (PCC). We conducted a study of 151 Brazilian PCC patients to analyze symptoms and immunoglobulin profiles, taking into account sex, vaccination, hospitalization, and age. Fatigue and myalgia were the most common symptoms, and lack of vaccination, hospitalization, and neuropsychiatric and metabolic comorbidities were relevant to the development of PCC. Analysis of serological immunoglobulins showed that IgA was higher in PCC patients, especially in the adult and elderly groups. Also, non-hospitalized and hospitalized PCC patients produced high and similar levels of IgA. Our results indicated that the detection of IgA antibodies against SARS-CoV-2 during the course of the disease could be associated with the development of PCC and may be an immunological signature to predict prolonged symptoms in COVID-19 patients.
COVID-19 已在全球范围内感染人类，导致数百万人死亡或幸存者出现长期症状。SARS-CoV-2 感染后的短暂或持续症状已被定义为新冠后状况（PCC）。我们对 151 名巴西 PCC 患者进行了研究，以分析症状和免疫球蛋白谱，同时考虑了性别、疫苗接种、住院和年龄等因素。疲劳和肌痛是最常见的症状，而缺乏疫苗接种、住院以及神经精神和代谢合并症与 PCC 的发展相关。血清免疫球蛋白分析表明，PCC 患者的 IgA 水平较高，尤其是在成年和老年组。此外，非住院和住院 PCC 患者产生的 IgA 水平较高且相似。我们的结果表明，在疾病过程中检测针对 SARS-CoV-2 的 IgA 抗体可能与 PCC 的发展有关，并且可能是预测 COVID-19 患者长期症状的免疫学特征。
