持续循环的严重急性呼吸综合征冠状病毒 2 刺突蛋白与急性冠状病毒病 2019 后遗症有关。
Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae.
机构信息
Harvard Medical School, Boston, Massachusetts, USA.
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
出版信息
Clin Infect Dis. 2023 Feb 8;76(3):e487-e490. doi: 10.1093/cid/ciac722.
Abstract
The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.
摘要
新型冠状病毒病 2019（COVID-19）后后遗症（PASC）的诊断是一个持续存在的医学挑战。为了确定与 PASC 相关的生物标志物，我们分析了从 PASC 和 COVID-19 患者采集的血浆样本，以定量检测病毒抗原和炎症标志物。我们发现，在诊断后长达 12 个月的时间里，严重急性呼吸综合征冠状病毒 2 的刺突蛋白主要存在于 PASC 患者体内。
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