Ertl Natalie, Lawn Will, Mokrysz Claire, Freeman Tom P, Alnagger Naji, Borissova Anna, Fernandez-Vinson Natalia, Lees Rachel, Ofori Shelan, Petrilli Kat, Trinci Katie, Viding Essi, Curran H Valerie, Wall Matthew B
Invicro London, Hammersmith Hospital, London, UK.
Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK.
J Psychopharmacol. 2023 Sep;37(9):904-919. doi: 10.1177/02698811231189441. Epub 2023 Jul 29.
BACKGROUND/AIM: Cannabis use is highly prevalent in adolescents; however, little is known about its effects on adolescent brain function.
Resting-state functional magnetic resonance imaging was used in matched groups of regular cannabis users ( = 70, 35 adolescents: 16-17 years old, 35 adults: 26-29 years old) and non-regular-using controls ( = 70, 35 adolescents/35 adults). Pre-registered analyses examined the connectivity of seven major cortical and sub-cortical brain networks (default mode network, executive control network (ECN), salience network, hippocampal network and three striatal networks) using seed-based analysis methods with cross-sectional comparisons between user groups and age groups.
The regular cannabis use group (across both age groups), relative to controls, showed localised increases in connectivity only in the ECN analysis. All networks showed localised connectivity differences based on age group, with the adolescents generally showing weaker connectivity than adults, consistent with the developmental effects. Mean connectivity across entire network regions of interest (ROIs) was also significantly decreased in the ECN in adolescents. However, there were no significant interactions found between age group and user group in any of the seed-based or ROI analyses. There were also no associations found between cannabis use frequency and any of the derived connectivity measures.
Regular cannabis use is associated with changes in connectivity of the ECN, which may reflect allostatic or compensatory changes in response to regular cannabis intoxication. However, these associations were not significantly different in adolescents compared to adults.
背景/目的：大麻在青少年中使用非常普遍；然而，对于其对青少年脑功能的影响却知之甚少。
对定期使用大麻的人群（n = 70，35名青少年：16 - 17岁，35名成年人：26 - 29岁）和非定期使用大麻的对照组（n = 70，35名青少年/35名成年人）进行静息态功能磁共振成像研究。预先注册的分析使用基于种子点的分析方法，对七个主要的皮质和皮质下脑网络（默认模式网络、执行控制网络（ECN）、突显网络、海马网络和三个纹状体网络）的连通性进行了横断面比较，比较了使用组和年龄组之间的差异。
定期使用大麻组（两个年龄组）相对于对照组，仅在执行控制网络分析中显示连通性局部增加。所有网络基于年龄组均显示出局部连通性差异，青少年的连通性普遍比成年人弱，这与发育效应一致。青少年执行控制网络中整个感兴趣网络区域（ROIs）的平均连通性也显著降低。然而，在任何基于种子点或感兴趣区域的分析中，均未发现年龄组和使用组之间存在显著交互作用。大麻使用频率与任何导出的连通性测量指标之间也未发现关联。
定期使用大麻与执行控制网络的连通性变化有关，这可能反映了对定期大麻中毒的适应性或代偿性变化。然而，与成年人相比，这些关联在青少年中并无显著差异。
