Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Cell Transplant. 2023 Jan-Dec;32:9636897231184596. doi: 10.1177/09636897231184596.
The immense neuroinflammation induced by multiple sclerosis (MS) promotes a favorable environment for ischemic stroke (IS) development, making IS a deadly complication of MS. The overlapping inflammation in MS and IS is a prelude to the vascular pathology, and an inherent cell death mechanism that exacerbates neurovascular unit (NVU) impairment in the disease progression. Despite this consequence, no therapies focus on reducing IS incidence in patients with MS. To this end, the preclinical and clinical evidence we review here argues for cell-based regenerative medicine that will augment the NVU dysfunction and inflammation to ameliorate IS risk.
多发性硬化症（MS）引起的巨大神经炎症促进了缺血性中风（IS）的发展，使 IS 成为 MS 的致命并发症。MS 和 IS 中的重叠炎症是血管病理学的前奏，也是一种内在的细胞死亡机制，加剧了疾病进展中神经血管单元（NVU）的损伤。尽管有这样的后果，但没有任何治疗方法专注于降低 MS 患者的 IS 发病率。为此，我们在这里回顾的临床前和临床证据表明，细胞再生医学将增强 NVU 的功能障碍和炎症，以降低 IS 的风险。
