Hermanussen M, Geiger-Benoit K, Sippell W G
Acta Paediatr Scand. 1986 Jul;75(4):601-4. doi: 10.1111/j.1651-2227.1986.tb10258.x.
Five growth hormone deficient children, aged 5.3 to 12.6 yrs, were measured regularly once or twice weekly by knemometry, a novel and noninvasive technique of accurate lower leg length measurement. The total period of observation was 40 months in the 5 children. During this time all children received replacement therapy with extractive human pituitary growth hormone 12 IU/m2/week by daily s.c. injections. 11 intermittent infectious illnesses occurred within the observation period of 40 months. During the infectious diseases a significant decrease of the mean lower leg growth velocity down to -0.012 mm/day was observed. During the following convalescent period (14 days) mean lower leg growth velocity rose up to +0.107 mm/day (p less than 0.001). Growth hormone substitution was not changed throughout the period of observation.
5名生长激素缺乏儿童，年龄在5.3至12.6岁之间，通过骨测量法进行定期测量，每周一次或两次，骨测量法是一种精确测量小腿长度的新型无创技术。5名儿童的总观察期为40个月。在此期间，所有儿童均接受了人垂体生长激素提取物替代治疗，剂量为12 IU/m²/周，通过每日皮下注射给药。在40个月的观察期内发生了11次间歇性感染性疾病。在感染性疾病期间，观察到小腿平均生长速度显著下降至-0.012毫米/天。在随后的恢复期（14天），小腿平均生长速度上升至+0.107毫米/天（p<0.001）。在整个观察期内，生长激素替代治疗没有改变。
