Department of Occupational Medicine, Medical University of Lublin, Jaczewskiego 8B, 20-090, Lublin, Poland.
Pharmacol Rep. 2023 Oct;75(5):1115-1125. doi: 10.1007/s43440-023-00512-1. Epub 2023 Jul 29.
Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a significant proportion of cancer-related deaths worldwide. Although conventional cancer therapies, such as surgical excision, chemotherapy, and radiation, have been used to treat malignant melanoma, their efficacy is often limited due to the development of resistance and adverse side effects. Therefore, there is a growing interest in developing alternative treatment options for melanoma that are more effective and less toxic. Terpenes, a diverse group of naturally occurring compounds of plant origin, have emerged as potential anticancer agents due to their ability to inhibit tumor growth and induce apoptosis in cancer cells. In this review, the current understanding of the anticancer effects of terpenes (including, thymoquinone, β-elemene, carvacrol, limonene, α-pinene, β-caryophyllene, perillyl alcohol, taxol, betulinic acid, α-bisabolol, ursolic acid, linalool, lupeol, and artesunate) was summarized, with a special focus on their potential as therapeutic agents for malignant melanoma.
黑色素瘤是一种高度侵袭性和危及生命的皮肤癌，占全球癌症相关死亡的很大比例。尽管传统的癌症疗法，如手术切除、化疗和放疗，已被用于治疗恶性黑色素瘤，但由于耐药性和不良反应的发展，其疗效往往有限。因此，人们越来越关注开发更有效、毒性更小的黑色素瘤替代治疗方案。萜类化合物是一类具有植物来源的多样化天然化合物，由于其能够抑制肿瘤生长和诱导癌细胞凋亡的能力，已成为潜在的抗癌药物。在这篇综述中，总结了萜类化合物（包括，百里醌、β-榄香烯、香芹酚、柠檬烯、α-蒎烯、β-石竹烯、紫苏醇、紫杉醇、桦木酸、α- 没药醇、熊果酸、芳樟醇、羽扇豆醇和青蒿琥酯）的抗癌作用的最新认识，特别关注它们作为治疗恶性黑色素瘤的治疗剂的潜力。
