Playing with FIRE: How an RXLR Oomycete Effector Fuels Disease by Hijacking 14-3-3 Proteins.

The plant pathogen causes rot disease in several monocots and dicots. The plant 14-3-3 proteins are targets of different types of effector molecules secreted by the pathogens. An RXLR-type effector FIRE (14-3-3 interacting RXLR effector) and its target 14-3-3 proteins that localize to haustoria have been identified, pointing to a potential site of interaction. The pathogen hijacks the host 14-3-3 proteins through FIRE-mediated interaction and lowers the immunity for disease progression. The effector FIRE and 14-3-3 interaction deciphered in this study could pave the way for genetic modification of plants with altered 14-3-3 protein for broad host resistance. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.