Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, U.S.A.
The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, U.K.
Mol Plant Microbe Interact. 2023 Jun;36(6):313-314. doi: 10.1094/MPMI-05-23-0062-CM. Epub 2023 Jul 29.
The plant pathogen causes rot disease in several monocots and dicots. The plant 14-3-3 proteins are targets of different types of effector molecules secreted by the pathogens. An RXLR-type effector FIRE (14-3-3 interacting RXLR effector) and its target 14-3-3 proteins that localize to haustoria have been identified, pointing to a potential site of interaction. The pathogen hijacks the host 14-3-3 proteins through FIRE-mediated interaction and lowers the immunity for disease progression. The effector FIRE and 14-3-3 interaction deciphered in this study could pave the way for genetic modification of plants with altered 14-3-3 protein for broad host resistance. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
植物病原菌可引起几种单子叶植物和双子叶植物的腐烂病。植物 14-3-3 蛋白是病原菌分泌的不同类型效应子分子的靶标。已经鉴定出一种 RXLR 型效应子 FIRE（与 14-3-3 相互作用的 RXLR 效应子）及其定位于吸器的靶标 14-3-3 蛋白，这指向了一个潜在的相互作用位点。病原菌通过 FIRE 介导的相互作用劫持宿主 14-3-3 蛋白，从而降低对疾病进展的免疫力。本研究中解析的效应子 FIRE 与 14-3-3 相互作用为遗传修饰植物以改变 14-3-3 蛋白从而获得广泛的宿主抗性铺平了道路。[公式：见正文] 版权所有 © 2023 作者。这是一篇基于 CC BY-NC-ND 4.0 国际许可协议下的开放获取文章。
