Changes of adrenal vasopressin during hemorrhagic shock in rats with hereditary diabetes insipidus (Brattleboro strain).

The adrenal gland of the Brattleboro rat contains AVP-like immunoassayable material in amounts equal to those of the normal Long Evans animal--6.180 ng/g fresh tissue in LE and 6.108 ng/g fresh tissue in the Brattleboro rats. After an activation of sympathetic NS and vasopressin secretion by hemorrhagic shock, the adrenal AVP-like material in LE increased by 54% and in Brattleboro rats--by 58%. After hemorrhagic shock plasma AVP in LE rats increased 3.5 fold, but in Brattleboro rats remained undetectable. The possible physiological role of adrenal AVP was discussed.