Ezzarani E A, Laulin J P, Brudieux R
Horm Metab Res. 1985 May;17(5):230-3. doi: 10.1055/s-2007-1013501.
Effects of water-deprivation on several metabolic parameters and on plasma aldosterone concentration have been investigated in male Brattleboro rats homozygous for hypothalamic diabetes insipidus (DI) and in male Long-Evans rats (LE) as controls. Two separate experiments were performed over a period of 72 hours: 1) to determine the global effect of water-deprivation, water deprived rats were compared with hydrated animals, 2) to elucidate the specific effect of dehydration alone, water-deprived rats were compared with similar food-restricted, but water-supplied DI and LE rats. In hydrated animals, plasma aldosterone concentration was close to 50% less in DI rats than in LE rats. After 72 hours, plasma aldosterone values increased mainly because of dehydration and this increase was greater in DI rats than in LE rats. At the same time, plasma aldosterone concentration remained lower in DI rats compared to LE rats. The changes in plasma aldosterone concentration after dehydration and possible reasons for the impairment of aldosterone production in DI rats are discussed.
在患有下丘脑性尿崩症（DI）的纯合雄性布拉德福德大鼠以及作为对照的雄性长 Evans 大鼠（LE）中，研究了缺水对几种代谢参数和血浆醛固酮浓度的影响。在 72 小时内进行了两项独立实验：1）为了确定缺水的总体影响，将缺水大鼠与饮水充足的动物进行比较；2）为了阐明单纯脱水的特定影响，将缺水大鼠与食物限制但饮水充足的 DI 和 LE 大鼠进行比较。在饮水充足的动物中，DI 大鼠的血浆醛固酮浓度比 LE 大鼠低近 50%。72 小时后，血浆醛固酮值主要因脱水而升高，且 DI 大鼠的这种升高幅度大于 LE 大鼠。同时，与 LE 大鼠相比，DI 大鼠的血浆醛固酮浓度仍然较低。讨论了脱水后血浆醛固酮浓度的变化以及 DI 大鼠醛固酮产生受损的可能原因。
