Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, 2108 Tupper Hall, One Shields Avenue, Davis, CA 95616, USA.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Vet Clin North Am Small Anim Pract. 2023 Nov;53(6):1309-1323. doi: 10.1016/j.cvsm.2023.06.002. Epub 2023 Jul 27.
Cardiogenic arterial thromboembolism (CATE) is a devastating complication in cats with cardiomyopathies with significant morbidity and mortality. Despite recent advances in the diagnosis and treatment of CATE, its recurrence and mortality remain high. This highlights the urgent need for a greater understanding of CATE pathophysiology so that novel diagnostic tests and therapeutics can be developed. This comprehensive review aims to summarize existing literature on pathophysiology, clinical diagnosis, and current recommendations on the prevention and treatment of CATE. It also identifies and describes knowledge gaps and research priorities in the roles of immunothrombosis and procoagulant platelets in the pathogenesis of CATE.
心源性动脉血栓栓塞症（CATE）是心肌病猫的一种毁灭性并发症，具有较高的发病率和死亡率。尽管最近在 CATE 的诊断和治疗方面取得了进展，但它的复发率和死亡率仍然很高。这突出表明，急需更好地了解 CATE 的病理生理学，以便开发新的诊断测试和治疗方法。本综述旨在总结目前关于 CATE 病理生理学、临床诊断以及预防和治疗的现有文献，并确定和描述免疫血栓形成和促凝血小板在 CATE 发病机制中的作用方面的知识空白和研究重点。
