解读微小RNA在多发性骨髓瘤发病机制中的作用：聚焦信号通路
Decoding the role of miRNAs in multiple myeloma pathogenesis: A focus on signaling pathways.
作者信息
Yehia Amr Mohamed, Elsakka Elsayed G E, Abulsoud Ahmed I, Abdelmaksoud Nourhan M, Elshafei Ahmed, Elkhawaga Samy Y, Ismail Ahmed, Mokhtar Mahmoud Mohamed, El-Mahdy Hesham A, Hegazy Maghawry, Elballal Mohammed S, Mohammed Osama A, El-Husseiny Hussein M, Midan Heba M, El-Dakroury Walaa A, Zewail Moataz B, Abdel Mageed Sherif S, Moustafa Yasser M, Mostafa Randa M, Elkady Mohamed A, Doghish Ahmed S
机构信息
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
出版信息
Pathol Res Pract. 2023 Aug;248:154715. doi: 10.1016/j.prp.2023.154715. Epub 2023 Jul 26.
Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in regulating gene expression in MM. Several non-coding RNAs have been demonstrated to regulate MM pathogenesis signaling pathways. These pathways might regulate MM development, apoptosis, progression, and therapeutic outcomes. They are Wnt/β-catenin, PI3K/Akt/mTOR, P53 and KRAS. This review highlights the impending role of miRNAs in MM signaling and their relationship with MM therapeutic interventions.
多发性骨髓瘤（MM）是一种浆细胞癌，近年来已得到广泛研究，研究人员越来越关注微小RNA（miRNA）在调节MM基因表达中的作用。几种非编码RNA已被证明可调节MM发病机制的信号通路。这些通路可能调节MM的发展、凋亡、进展和治疗结果。它们是Wnt/β-连环蛋白、PI3K/Akt/mTOR、P53和KRAS。本综述强调了miRNA在MM信号传导中的重要作用及其与MM治疗干预的关系。
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