Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
Theory & Simulation Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
Int J Biol Macromol. 2023 Dec 1;252:126015. doi: 10.1016/j.ijbiomac.2023.126015. Epub 2023 Jul 29.
Composite hydrogels of Na-Alginate (Na-ALG) and Gelatin (GEL) with conducting polymers (CPs) were synthesised using poly(o-phenylenediamine) (POPD), polyaniline (PANI), poly(1-naphthylamine (PNA) and poly(vinylenedine fluoride) (PVDF). The synthesised hydrogels were characterized using FTIR, scanning electron microscopy (SEM) rheology, swelling ability and in-vitro drug release characteristics. The purpose of this investigation was to determine whether these hydrogels could be used to deliver antibiotics for extended drug release. The composite hydrogels were loaded with antibiotic drug: amoxicillin in three different concentrations and the release was studied at intestinal fluid (pH 7.4) and gastric fluid (pH 1.2). Release kinetics was found to show best fit in zero order models at both pH values and showed prolonged release characteristics. The POPD-Na-ALG/GEL showed highest release at intestinal pH of 7.4, while PVDF-Na-ALG/GEL showed highest release at gastric pH at 1.2.
使用聚邻苯二胺（POPD）、聚苯胺（PANI）、聚 1-萘胺（PNA）和聚偏氟乙烯（PVDF）合成了 Na-海藻酸钠（Na-ALG）和明胶（GEL）与导电聚合物（CPs）的复合水凝胶。通过傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、流变学、溶胀能力和体外药物释放特性对合成水凝胶进行了表征。本研究的目的是确定这些水凝胶是否可用于输送抗生素以实现延长的药物释放。将抗生素药物：阿莫西林以三种不同浓度负载到复合水凝胶中，并在肠液（pH 7.4）和胃液（pH 1.2）中研究释放情况。在两种 pH 值下，释放动力学均表现出最适合零级模型，并且表现出延长的释放特性。在 pH 7.4 的肠液中，POPD-Na-ALG/GEL 表现出最高的释放率，而在 pH 1.2 的胃液中，PVDF-Na-ALG/GEL 表现出最高的释放率。
