Faculty of Chemical Engineering, Urmia University of Technology, Urmia, Iran.
Applied Chemistry Department, Urmia University of Technology, Urmia, Iran.
J Biomater Sci Polym Ed. 2024 Apr;35(4):463-481. doi: 10.1080/09205063.2023.2295058. Epub 2023 Dec 21.
This study deals with preparing and characterizing polyvinyl alcohol/egg white/montmorillonite bionanocomposite hydrogels as antibacterial drug delivery systems. The cyclic freezing/thawing method was utilized to fabricate the hydrogels. To study the performance of the prepared hydrogels as drug delivery systems, amoxicillin, as a model antibiotic drug, was loaded into the hydrogels by mixing with the precursor polymer solution and gelation. From the diverse microstructural characterization techniques, i.e. XRD, SEM, AFM, DLS, and gel fraction estimation, it was possible to infer that montmorillonite has been successfully incorporated into the hydrogel network and acted as an additional crosslinker to bind the chains of egg white and polyvinyl alcohol. Scrutinizing the physical properties of the produced hydrogels demonstrated that increasing incorporated montmorillonite content adversely affects the prepared hydrogels' swelling ability and prolongs their dehydration period. Additionally, the Swelling characteristics of the hydrogels were evaluated at different pHs. Results showed an increase in the swelling ability of all samples by raising the pH value of the medium. Additionally, it was proved that both swelling and dehydration of the hydrogels follow non-Fickian diffusion. drug delivery experiments demonstrated that the cumulative fractional release of amoxicillin was adversely dependent on the amount of incorporated montmorillonite into the hydrogels and positively dependent on the pH of the release solution. It was also found that, in all examined samples, the mechanism by which the release of clindamycin happens is non-Fickian or anomalous transport.
本研究致力于制备和表征聚乙烯醇/蛋清/蒙脱土生物纳米复合水凝胶作为抗菌药物递送系统。采用循环冷冻/解冻法制备水凝胶。为了研究所制备的水凝胶作为药物递送系统的性能，将阿莫西林作为模型抗生素药物通过与前体聚合物溶液混合并凝胶化而载入水凝胶中。通过各种微观结构表征技术，即 XRD、SEM、AFM、DLS 和凝胶分数估算，推断蒙脱土已成功掺入水凝胶网络中，并作为额外的交联剂结合蛋清和聚乙烯醇的链。仔细研究所制备的水凝胶的物理性能表明，增加掺入的蒙脱土含量会对水凝胶的溶胀能力产生不利影响，并延长其脱水时间。此外，还在不同 pH 值下评估了水凝胶的溶胀特性。结果表明，通过提高介质的 pH 值，所有样品的溶胀能力都有所增加。此外，还证明了水凝胶的溶胀和脱水都遵循非菲克扩散。药物释放实验表明，阿莫西林的累积释放分数与水凝胶中掺入的蒙脱土量成反比，与释放溶液的 pH 值成正比。还发现，在所有检查的样品中，克林霉素释放的机制是非菲克或异常传输。
