College of Chemistry and Materials Science, Hebei University, Baoding City, Hebei Province 071002, China.
Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Diseases in Hebei Province, Hebei University, Baoding City, Hebei Province 071002, China.
Int J Biol Macromol. 2023 Sep 30;249:126012. doi: 10.1016/j.ijbiomac.2023.126012. Epub 2023 Jul 29.
The self-healing hydrogels have important applications in biomedication as drug release carrier. In this research, the Doxorubicin (DOX) was coupled onto oxidized carboxymethylcellulose (CMC) (CMC-Ald) to fabricate self-healing hydrogel with intrinsic antitumor property and loaded with Camptothecin (CPT) for synergetic antitumor treatment. The DOX coupled CMC-Ald (CMC-AD) was reacted with poly(aspartic hydrazide) (PAH) to fabricate injectable self-healing hydrogel. The coupled DOX avoided the burst release of the drug and the 100 % CPT loaded hydrogel could take the advantages of both drugs to enhance the synergetic antitumor therapeutic effect. The in vitro and in vivo results revealed the CPT loaded CMC-AD/PAH hydrogel showed enhanced antitumor property and reduced biotoxicity of the drugs. These properties demonstrate that the CMC-AD/PAH hydrogel has great application prospects in biomedication.
自修复水凝胶在作为药物释放载体的生物医药中有重要应用。在这项研究中，阿霉素（DOX）被偶联到氧化羧甲基纤维素（CMC）（CMC-Ald）上，以制备具有内在抗肿瘤特性的自修复水凝胶，并负载喜树碱（CPT）以进行协同抗肿瘤治疗。偶联 DOX 的 CMC-Ald（CMC-AD）与聚（天冬氨酸酰肼）（PAH）反应，制备可注射的自修复水凝胶。偶联的 DOX 避免了药物的爆发释放，而 100%载药的水凝胶可以利用两种药物的优势，增强协同抗肿瘤治疗效果。体外和体内结果表明，载 CPT 的 CMC-AD/PAH 水凝胶表现出增强的抗肿瘤特性和降低的药物生物毒性。这些特性表明 CMC-AD/PAH 水凝胶在生物医药中有很大的应用前景。
