College of Chemistry and Environmental Science, Hebei University, Baoding City, Hebei Province 071002, China.
Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Diseases in Hebei Province, Hebei University, Baoding City, Hebei Province 071002, China.
Int J Biol Macromol. 2023 Mar 1;230:123294. doi: 10.1016/j.ijbiomac.2023.123294. Epub 2023 Jan 14.
The application of biodegradable hydrogels in medical field has drawn great attention because their networked structure provided ideal spaces for drug loading and cell growth. In this research, the boronic acid was coupled onto carboxyethyl cellulose (CMC) to synthesize boronic acid grafted CMC (CMC-BA) conveniently and self-healing hydrogel was fabricated with polyvinyl alcohol (PVA) crosslinking through dynamic boronic ester bond. The CMC-BA/PVA hydrogel showed good biocompatibility and could be degraded by cellulase and in vivo. The hydrogel formed fast fit for localized injection to cover the irregular wounds and localize the antitumor drugs to the tumor site. The in vivo wound repairing experiment revealed the hydrogel could form airtight adhesion to the wound site to reduce blood loss and accelerate the wound repairing rate. The hydrogel as a drug release carrier also reduced the acute in vivo toxicity of DOX with antitumor performance well preserved through a controlled release profile. Based on the above advantages, the CMC-based hydrogel with boronic ester connection should have great potential in biomedical areas with profitable future.
可生物降解水凝胶在医学领域的应用引起了极大的关注，因为其网络结构为药物负载和细胞生长提供了理想的空间。本研究通过将硼酸接枝到羧乙基纤维素（CMC）上，方便地合成了硼酸接枝 CMC（CMC-BA），并通过动态硼酸酯键与聚乙烯醇（PVA）交联制备了自修复水凝胶。CMC-BA/PVA 水凝胶具有良好的生物相容性，可被纤维素酶和体内降解。水凝胶形成迅速，适用于局部注射，以覆盖不规则伤口，并将抗肿瘤药物定位到肿瘤部位。体内伤口修复实验表明，水凝胶可以与伤口部位紧密贴合，减少出血并加速伤口愈合速度。水凝胶作为药物释放载体，也降低了 DOX 的急性体内毒性，通过控制释放曲线保持了良好的抗肿瘤性能。基于以上优点，基于硼酸酯键的 CMC 水凝胶在生物医学领域具有很大的应用潜力，前景广阔。
