Ishikawa Yuichi, Urabe Hiroaki, Yamada Yuya, Yamamura Kenichiro, Tao Katsuo, Suzuki Sayo, Muraji Shota, Kuraoka Ayako, Sagawa Koichi
Department of Cardiology, Fukuoka Children's Hospital.
Department of Radiology, Fukuoka Children's Hospital.
Int Heart J. 2023;64(4):663-671. doi: 10.1536/ihj.23-022.
Age-related mean and reference ranges for ventricular volumes and mass, regional blood flow measurements, and T1 values using cardiovascular magnetic resonance (CMR) imaging are yet to be established for the pediatric population. Especially in infants and toddlers, no consistent flow volume sets or T1 values have been reported. The purpose of this study was to determine the relevant normal values.Twenty-three children (aged 0.1-15.3 years) without cardiovascular diseases were included. Comprehensive CMR imaging including cine, 2-dimensional phase-contrast, and native T1 mapping, were performed. Ventricular volumes and masses, 11 sets of regional blood flow volumes, and myocardial and liver T1 values were measured. All intraclass correlation coefficient values were > 0.94, except for the right ventricular mass (0.744), myocardial (0.868) and liver T1 values (0.895), reflecting good to excellent agreement between rates.Regression analysis showed an exponential relationship between body surface area (BSA) and ventricular volumes, mass, and regional blood flow volumes (normal value = aBSA). Left ventricular myocardial T1 values were regressed on linear regression with age (normal value = -7.39age + 1091), and hepatic T1 values were regressed on a quadratic function of age (normal value = 0.923age -18.012age + 613).Comparison of the 2 different methods for the same physical quantities by Bland-Altman plot showed no difference except that the right ventricular stroke volume was 1.5 mL larger than the main pulmonary trunk flow volume.This study provides the normal values for comprehensive CMR imaging in Japanese children.
心血管磁共振（CMR）成像用于测量心室容积、质量、局部血流量以及T1值的年龄相关均值和参考范围，在儿科人群中尚未确立。特别是在婴幼儿中，尚未有一致的血流量数据集或T1值的报道。本研究的目的是确定相关的正常值。纳入了23名无心血管疾病的儿童（年龄0.1 - 15.3岁）。进行了包括电影成像、二维相位对比成像和T1值原始成像的综合CMR成像。测量了心室容积和质量、11组局部血流量以及心肌和肝脏的T1值。除右心室质量（0.744）、心肌（0.868）和肝脏T1值（0.895）外，所有组内相关系数值均>0.94，反映出各测量值之间具有良好至极佳的一致性。回归分析显示体表面积（BSA）与心室容积、质量和局部血流量之间呈指数关系（正常值 = a×BSA）。左心室心肌T1值与年龄呈线性回归（正常值 = -7.39×年龄 + 1091），肝脏T1值与年龄呈二次函数回归（正常值 = 0.923×年龄² - 18.012×年龄 + 613）。通过Bland - Altman图对相同物理量的两种不同测量方法进行比较，结果显示除右心室每搏输出量比主肺动脉血流量大1.5 mL外，无差异。本研究提供了日本儿童综合CMR成像的正常值。
