脱咖啡因咖啡提取物的制备：脱咖啡因咖啡提取物对降低2型糖尿病患者血糖有效性的研究。

Preparation of decaffeinated coffee extract: study of the effectiveness of decaffeinated coffee extract toward lowering blood sugar in type 2 diabetes mellitus patients.

作者信息

Lestari S, Sunaryo T, Arvianto R I

机构信息

Nursing Department of Health Polytechnic, Ministry of Health, Surakarta, Indonesia.

Sebelas Maret University, Faculty of Engineering, Engineering Department, Surakarta, Indonesia.

出版信息

Med J Malaysia. 2023 Jul;78(4):515-518.

PMID:37518924

Abstract

INTRODUCTION

Diabetes mellitus is a disease characterized by an increase in blood sugar levels due to abnormalities in the insulin hormone system. The number of people with this disease is expected to increase every year. Therefore, it is necessary to develop diabetes mellitus drugs that have effective performance in reducing blood glucose level. Coffee contain chlorogenic acid and caffeine. Chlorogenic acid play a role in increasing insulin sensitivity. However, the caffeine causes a decrease in glucose tolerance. The removal of caffeine or the decaffeination process is expected to improve the quality of coffee as an anti-diabetic drug. The aim of this study was to investigate the effectiveness of decaffeinated coffee extract in reducing blood sugar.

MATERIALS AND METHODS

Green or roasted coffee extract was decaffeinated using activated charcoal. Decaffeinated coffee extract with the lowest caffeine and the highest chlorogenic acid based on HPLC measurement was used for antidiabetic test. The anti-diabetic test was conducted with 52 DM type 2 patient selected by purposive sample. The test were divided into two groups: intervention (26 respondents) and control group (26 respondents). The data were analysed by Paired and Independent t test.

RESULTS

Decaffeinated green coffee extract is very suitable for use as a drug to lower blood sugar in DM type 2 patients than decaffeinated roasted coffee extract because of higher in chlorogenic acid and lower in caffeine (Figure 2). Treatment by decaffeinated green coffee extract for 3 weeks showed a significant decrease in average fasting blood glucose level from 144.7 g/dl to 92.23 g/dl. All statistical tests showed a p value = 0.001 (below the significant value), this value proves the success of reducing blood glucose by decaffeinated green coffee extract.

CONCLUSION

The decaffeinated green coffee extract decreases fasting blood sugar significantly.

摘要

引言

糖尿病是一种由于胰岛素激素系统异常导致血糖水平升高的疾病。预计每年患这种疾病的人数都会增加。因此，有必要开发在降低血糖水平方面具有有效性能的糖尿病药物。咖啡含有绿原酸和咖啡因。绿原酸在提高胰岛素敏感性方面发挥作用。然而，咖啡因会导致葡萄糖耐量降低。去除咖啡因或进行脱咖啡因过程有望提高咖啡作为抗糖尿病药物的质量。本研究的目的是调查脱咖啡因咖啡提取物在降低血糖方面的有效性。

材料与方法

使用活性炭对生咖啡或烘焙咖啡提取物进行脱咖啡因处理。基于高效液相色谱测量，选择咖啡因含量最低且绿原酸含量最高的脱咖啡因咖啡提取物进行抗糖尿病测试。抗糖尿病测试针对通过目的抽样选择的52名2型糖尿病患者进行。测试分为两组：干预组（26名受访者）和对照组（26名受访者）。数据通过配对t检验和独立t检验进行分析。

结果

脱咖啡因的生咖啡提取物比脱咖啡因的烘焙咖啡提取物更适合用作降低2型糖尿病患者血糖的药物，因为其绿原酸含量更高且咖啡因含量更低（图2）。用脱咖啡因的生咖啡提取物治疗3周后，平均空腹血糖水平从144.7克/分升降至92.23克/分升，显著下降。所有统计检验显示p值 = 0.001（低于显著值），该值证明脱咖啡因的生咖啡提取物降低血糖成功。