脱咖啡因咖啡与年轻男性的葡萄糖代谢。
Decaffeinated coffee and glucose metabolism in young men.
机构信息
Department of Health and Nutrition Sciences, Brooklyn College of the City, University of New York, New York, New York, USA.
出版信息
Diabetes Care. 2010 Feb;33(2):278-80. doi: 10.2337/dc09-1539. Epub 2009 Nov 16.
Abstract
OBJECTIVE
The epidemiological association between coffee drinking and decreased risk of type 2 diabetes is strong. However, caffeinated coffee acutely impairs glucose metabolism. We assessed acute effects of decaffeinated coffee on glucose and insulin levels.
RESEARCH DESIGN AND METHODS
This was a randomized, cross-over, placebo-controlled trial of the effects of decaffeinated coffee, caffeinated coffee, and caffeine on glucose, insulin, and glucose-dependent insulinotropic polypeptide (GIP) levels during a 2-h oral glucose tolerance test (OGTT) in 11 young men.
RESULTS
Within the first hour of the OGTT, glucose and insulin were higher for decaffeinated coffee than for placebo (P < 0.05). During the whole OGTT, decaffeinated coffee yielded higher insulin than placebo and lower glucose and a higher insulin sensitivity index than caffeine. Changes in GIP could not explain any beverage effects on glucose and insulin.
CONCLUSIONS
Some types of decaffeinated coffee may acutely impair glucose metabolism but less than caffeine.
摘要
目的
喝咖啡与 2 型糖尿病风险降低之间存在很强的流行病学关联。然而，含咖啡因的咖啡会急性损害葡萄糖代谢。我们评估了脱咖啡因咖啡对葡萄糖和胰岛素水平的急性影响。
研究设计和方法
这是一项随机、交叉、安慰剂对照试验，研究了在 11 名年轻男性的 2 小时口服葡萄糖耐量试验 (OGTT) 期间，脱咖啡因咖啡、含咖啡因咖啡和咖啡因对葡萄糖、胰岛素和葡萄糖依赖性胰岛素释放肽 (GIP) 水平的影响。
结果
在 OGTT 的前 1 小时内，脱咖啡因咖啡组的葡萄糖和胰岛素水平高于安慰剂组 (P < 0.05)。在整个 OGTT 期间，脱咖啡因咖啡组的胰岛素水平高于安慰剂组，葡萄糖水平低于安慰剂组，胰岛素敏感性指数高于咖啡因组。GIP 的变化不能解释任何饮料对葡萄糖和胰岛素的影响。
结论
某些类型的脱咖啡因咖啡可能会急性损害葡萄糖代谢，但程度低于咖啡因。
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