Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Ann Clin Transl Neurol. 2023 Oct;10(10):1891-1898. doi: 10.1002/acn3.51859. Epub 2023 Jul 30.
We performed a cross-sectional study to determine associations between cognition and MRI-derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): -0.0061, 95%CI: -0.0113, -0.0009, n = 45), gray matter volume (PE: -830.39, 95%CI: -1503.14, -157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).
我们进行了一项横断面研究，旨在确定认知与肥胖、糖尿病病程和代谢风险因素与 51 例患有长期 2 型糖尿病（T2d）的皮马印第安人（平均[SD]年龄：48.4[11.3]岁，T2d 病程：20.1[9.1]年）之间的关系。参与者的认知能力与正常值相似（NIH 工具包认知电池综合评分：45.3[9.8]，p=0.64，n=51）。与其他代谢风险因素相比，T2d 病程与皮质厚度降低（点估计（PE）：-0.0061，95%CI：-0.0113，-0.0009，n=45）、灰质体积减少（PE：-830.39，95%CI：-1503.14，-157.64，n=45）和白质高信号体积增加（PE：0.0389，95%CI：0.0049，0.0729，n=45）相关。
