糖尿病患者的大脑健康结果与代谢风险因素之间的关联。
Association between brain health outcomes and metabolic risk factors in persons with diabetes.
机构信息
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
出版信息
Ann Clin Transl Neurol. 2023 Oct;10(10):1891-1898. doi: 10.1002/acn3.51859. Epub 2023 Jul 30.
We performed a cross-sectional study to determine associations between cognition and MRI-derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): -0.0061, 95%CI: -0.0113, -0.0009, n = 45), gray matter volume (PE: -830.39, 95%CI: -1503.14, -157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).
我们进行了一项横断面研究，旨在确定认知与肥胖、糖尿病病程和代谢风险因素与 51 例患有长期 2 型糖尿病（T2d）的皮马印第安人（平均[SD]年龄：48.4[11.3]岁，T2d 病程：20.1[9.1]年）之间的关系。参与者的认知能力与正常值相似（NIH 工具包认知电池综合评分：45.3[9.8]，p=0.64，n=51）。与其他代谢风险因素相比，T2d 病程与皮质厚度降低（点估计（PE）：-0.0061，95%CI：-0.0113，-0.0009，n=45）、灰质体积减少（PE：-830.39，95%CI：-1503.14，-157.64，n=45）和白质高信号体积增加（PE：0.0389，95%CI：0.0049，0.0729，n=45）相关。
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