Faraz Simra, Khan Abu Taleb
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India.
Org Biomol Chem. 2023 Sep 27;21(37):7553-7560. doi: 10.1039/d3ob00993a.
An environmentally benign and metal-free synthesis of 4-aryl quinolines is reported by employing readily available arylamine, arylacetylene, and DMSO in the presence of 20 mol% -TSA·HO. In the present protocol, the solvent DMSO serves as a reactant cum solvent for providing the C2 carbon atom of the quinoline skeleton. Notably, the reaction proceeds effectively and efficiently without the involvement of any metal catalyst, ligand, and co-catalyst as additives and inert atmospheric reaction conditions. This method provides high atom economy and good yields, and two - and one - bonds are formed in a single step through a three-component reaction.
报道了一种环境友好且无金属的4-芳基喹啉合成方法，该方法使用易得的芳胺、芳基乙炔和二甲基亚砜，在20 mol%的对甲苯磺酸一水合物存在下进行反应。在本方法中，溶剂二甲基亚砜既作为反应物又作为溶剂，用于提供喹啉骨架的C2碳原子。值得注意的是，该反应在不涉及任何金属催化剂、配体和助催化剂作为添加剂以及惰性气氛反应条件下有效地进行。此方法具有高原子经济性和良好的产率，通过三组分反应一步形成两根和一根化学键。
