Medeiros-Oliveira Vanessa Cassia, Viana Raytta Silva, Oliveira Ariclecio Cunha de, Nascimento-Ferreira Marcus Vinicius, De Moraes Augusto César Ferreira
Department of Epidemiology, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil.
YCARE (Youth/Child and cArdiovascular Risk and Environmental) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Prev Med Rep. 2023 Jul 17;35:102327. doi: 10.1016/j.pmedr.2023.102327. eCollection 2023 Oct.
Sleep restriction in children can trigger the development of problems such as impaired cognition, behavioral problems, cardiovascular problems, and obesity. In addition, the inflammatory profile of children can also be influenced by sleep restriction. The aimed to review and analyze the association between time and sleep quality with inflammatory biomarkers in children and adolescents. Three electronic databases (MEDLINE, Web of Science and Scopus) were searched from August 30, 2022. The search strategy used the following descriptors: children and adolescents; sleep, and inflammatory profile. This review protocol is registered in the PROSPERO database (CRD42020188969). We obtained 2.724 results of articles with potentially relevant titles. Sixteen percent of the articles were excluded because they were duplicates, 84.3% were excluded after reading the title, and 0.9% were studied from systematic reviews or textbooks (0.9%). Accelerometers are the most commonly used method for the objective measurement of sleep time, while the PSQI questionnaire is the most commonly used subjective method to measure sleep quality. The results indicated an inconsistent association between sleep time and CRP in the literature. Sixty percent of studies used the Pittsburgh Sleep Quality Index (PSQI) for subjective assessment of sleep quality and possible sleep disorders. However, only one retrieved study showed significant association between sleep quality and CRP. Thus, sleep time does not present significant association with inflammatory biomarkers; whereas, poor sleep quality shows positive association with CRP with a lower magnitude.
儿童睡眠受限会引发认知障碍、行为问题、心血管问题和肥胖等问题。此外，睡眠受限还会影响儿童的炎症指标。本研究旨在回顾和分析儿童及青少年的睡眠时间和睡眠质量与炎症生物标志物之间的关联。于2022年8月30日检索了三个电子数据库（MEDLINE、Web of Science和Scopus）。检索策略使用了以下描述词：儿童和青少年；睡眠和炎症指标。本综述方案已在PROSPERO数据库（CRD42020188969）中注册。我们获得了2724篇标题可能相关的文章。其中16%的文章因重复被排除，84.3%在阅读标题后被排除，0.9%来自系统评价或教科书（0.9%）。加速度计是客观测量睡眠时间最常用的方法，而PSQI问卷是主观测量睡眠质量最常用的方法。结果表明，文献中睡眠时间与CRP之间的关联并不一致。60%的研究使用匹兹堡睡眠质量指数（PSQI）对睡眠质量和可能的睡眠障碍进行主观评估。然而，检索到的研究中只有一项显示睡眠质量与CRP之间存在显著关联。因此，睡眠时间与炎症生物标志物之间不存在显著关联；而睡眠质量差与CRP呈正相关，但相关性较弱。
