Mayovska Oksana V, Rosenstein Elliot D, Kramer Neil
Internal Medicine, Morristown Medical Center, Morristown, USA.
Rheumatology, Overlook Medical Center, Summit, USA.
Cureus. 2023 Jun 26;15(6):e41000. doi: 10.7759/cureus.41000. eCollection 2023 Jun.
Clinically significant granulomatous inflammation of skeletal muscle in sarcoidosis is rare. Glucocorticoids are generally considered the first-line treatment of sarcoidosis, but due to their side effect profile, the addition of steroid-sparing regimens has become increasingly more common. We report a patient with nodular sarcoid myositis who was successfully treated with antimalarial hydroxychloroquine alone. Whereas antimalarials have been reported to be an effective treatment of various organ involvement in sarcoidosis, to our knowledge, this is the first report of hydroxychloroquine monotherapy successfully treating nodular sarcoid myositis. Hydroxychloroquine monotherapy may be a reasonable initial treatment option for nodular sarcoid myositis and other forms of muscular sarcoidosis, as well as for other non-acute organ-threatening manifestations of the disease.
结节病中具有临床意义的骨骼肌肉芽肿性炎症较为罕见。糖皮质激素通常被认为是结节病的一线治疗药物，但由于其副作用，添加激素节省方案变得越来越普遍。我们报告了一名结节性结节病性肌炎患者，仅使用抗疟药羟氯喹就成功治愈。尽管已有报道称抗疟药可有效治疗结节病累及的各种器官，但据我们所知，这是羟氯喹单药成功治疗结节性结节病性肌炎的首例报告。羟氯喹单药治疗可能是结节性结节病性肌炎和其他形式的肌肉结节病，以及该疾病其他非急性威胁器官表现的合理初始治疗选择。
