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炎症性肠病的进展:关于诊断、管理、流行病学、患病率、患者预后、生活质量及临床表现的叙述性综述

Advancements in Inflammatory Bowel Disease: A Narrative Review of Diagnostics, Management, Epidemiology, Prevalence, Patient Outcomes, Quality of Life, and Clinical Presentation.

作者信息

Muzammil Muhammad Ali, Fariha Fnu, Patel Tirath, Sohail Rohab, Kumar Munesh, Khan Ejaz, Khanam Bushra, Kumar Satesh, Khatri Mahima, Varrassi Giustino, Vanga Prasanthi

机构信息

Internal Medicine, Dow University of Health Sciences, Karachi, Karachi, PAK.

Medicine, Dow University of Health Sciences, Karachi, Karachi, PAK.

出版信息

Cureus. 2023 Jun 28;15(6):e41120. doi: 10.7759/cureus.41120. eCollection 2023 Jun.

Abstract

Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is a chronic, immune-mediated disorder that impacts the gastrointestinal tract. Significant advancements in the diagnosis and treatment of IBD have been made during the past few decades, improving patient outcomes. This narrative review aims to provide an overview of recent developments in the diagnosis and treatment of IBD. Both from an evaluative and therapeutic standpoint, the management of IBD has undergone significant change. The standard of treatment for treating UC and CD patients has changed due to several medical developments. These developments include amino-salicylates, immunosuppressants, biological agents, and new therapeutics. The review also addresses the difficulties in applying these developments in clinical practice. Globally, the prevalence of IBD is rising, with Asia among the regions with the highest rates. These environments provide particular difficulties, such as poor disease knowledge, a lack of diagnostic services, and infectious IBD mimics. These issues must be resolved to diagnose and manage IBD in these populations accurately. New imaging modalities and other improvements in diagnostic methods have increased the precision and early identification of IBD. To reduce problems and improve patient outcomes, healthcare professionals treating patients with IBD must work effectively as a team. An extensive summary of current developments in the diagnosis and treatment of IBD is given in this narrative review. It draws attention to the therapeutic possibilities, difficulties, and uncertainties of integrating these developments into clinical practice. By keeping up with these changes, healthcare practitioners can better care for patients with IBD and improve their quality of life.

摘要

炎症性肠病(IBD)包括溃疡性结肠炎(UC)和克罗恩病(CD),是一种影响胃肠道的慢性免疫介导性疾病。在过去几十年中,IBD的诊断和治疗取得了重大进展,改善了患者的治疗效果。本叙述性综述旨在概述IBD诊断和治疗的最新进展。从评估和治疗的角度来看,IBD的管理都发生了重大变化。由于多项医学进展,UC和CD患者的治疗标准已经改变。这些进展包括氨基水杨酸类药物、免疫抑制剂、生物制剂和新疗法。该综述还讨论了在临床实践中应用这些进展所面临的困难。在全球范围内,IBD的患病率正在上升,亚洲是患病率最高的地区之一。这些环境带来了特殊的困难,如疾病知识匮乏、缺乏诊断服务以及感染性IBD模仿疾病。必须解决这些问题,才能准确诊断和管理这些人群中的IBD。新的成像方式和诊断方法的其他改进提高了IBD诊断的准确性和早期识别率。为了减少问题并改善患者的治疗效果,治疗IBD患者的医护人员必须作为一个团队有效地开展工作。本叙述性综述对IBD诊断和治疗的当前进展进行了广泛总结。它提请人们注意将这些进展整合到临床实践中的治疗可能性、困难和不确定性。通过跟上这些变化,医护人员可以更好地照顾IBD患者并提高他们的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab5c/10382792/1ab041a30148/cureus-0015-00000041120-i01.jpg

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