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人体器官中细胞视黄醇结合蛋白的定量分析。

Quantitation of cellular retinol-binding protein in human organs.

作者信息

Ong D E, Page D L

出版信息

Am J Clin Nutr. 1986 Sep;44(3):425-30. doi: 10.1093/ajcn/44.3.425.

DOI:10.1093/ajcn/44.3.425
PMID:3751963
Abstract

Levels of cellular retinol-binding protein (CRBP) have been determined for a number of human tissues by a sensitive radioimmunoassay. The protein was detectable in at least one sample of every tissue examined. Samples with the highest levels were obtained from adrenal, liver, ovary, pituitary, and testis. The relative abundance of CRBP was significantly different from the relative abundance for rat organs. The wide distribution of CRBP in human organs stresses the importance of this protein in the metabolism of vitamin A throughout the body.

摘要

已通过灵敏的放射免疫测定法测定了多种人体组织中的细胞视黄醇结合蛋白(CRBP)水平。在所检测的每个组织的至少一个样本中都可检测到该蛋白。CRBP水平最高的样本取自肾上腺、肝脏、卵巢、垂体和睾丸。CRBP在人体器官中的相对丰度与大鼠器官的相对丰度显著不同。CRBP在人体器官中的广泛分布强调了该蛋白在全身维生素A代谢中的重要性。

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Quantitation of cellular retinol-binding protein in human organs.人体器官中细胞视黄醇结合蛋白的定量分析。
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引用本文的文献

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Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases.细胞视黄醇结合蛋白、CRBP、CRABP、FABP5:对视黄醇代谢、功能及相关疾病的影响。
Pharmacol Ther. 2017 May;173:19-33. doi: 10.1016/j.pharmthera.2017.01.004. Epub 2017 Jan 27.
2
Functions of Intracellular Retinoid Binding-Proteins.细胞内类视黄醇结合蛋白的功能。
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3
The relations between dietary antioxidant vitamins intake and oxidative stress in follicular fluid and ART outcomes.
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Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenase.人类酶RDH10的动力学分析确定了一种生理相关视黄醇脱氢酶的特性。
J Biol Chem. 2008 Jul 18;283(29):20299-308. doi: 10.1074/jbc.M800019200. Epub 2008 May 23.
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Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.纯化的人视黄醇脱氢酶12(RDH12)的生化特性:对类视黄醇和C9醛的催化效率以及I型细胞视黄醇结合蛋白(CRBPI)和细胞视黄醛结合蛋白(CRALBP)对类视黄醇氧化和还原的影响。
Biochemistry. 2005 May 10;44(18):7035-47. doi: 10.1021/bi050226k.
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Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein.一种人视黄醇结合蛋白的鉴定、类视黄醇结合及X射线分析。
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3710-5. doi: 10.1073/pnas.061455898.
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Cellular binding proteins for fatty acids and retinoids: similar or specialized functions?脂肪酸和类视黄醇的细胞结合蛋白:功能相似还是具有特异性?
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