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分散在藻酸盐水凝胶中的紫堇负载壳聚糖纳米颗粒通过上调血管内皮生长因子（VEGF）、转化生长因子-β（TGF-β）和碱性成纤维细胞生长因子（b-FGF）基因促进糖尿病伤口愈合：一项临床前研究。

Fumaria officinalis-loaded chitosan nanoparticles dispersed in an alginate hydrogel promote diabetic wounds healing by upregulating VEGF, TGF-β, and b-FGF genes: A preclinical investigation.

作者信息

Yang Xi, Mo Wenqian, Shi Yan, Fang Xiang, Xu Yujian, He Xiaoqing, Xu Yongqing

机构信息

Department of Orthopedics, 920 Hospital of Joint Logistic Support Force, Kunming, 650000, China.

Department of Pathology, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, 650000, China.

出版信息

Heliyon. 2023 Jun 29;9(7):e17704. doi: 10.1016/j.heliyon.2023.e17704. eCollection 2023 Jul.

DOI:10.1016/j.heliyon.2023.e17704
PMID:37519642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10372204/
Abstract

Diabetic wounds may become chronic if left untreated. In the current study, a potential wound dressing was developed by incorporating fumaria officinalis extract-loaded chitosan nanoparticles (FOE-CHNPs) into calcium alginate hydrogel. The produced hydrogel was evaluated regarding its microarchitecture, cytotoxicity, cell migration activity, cytoprotective potential, porosity, in vitro anti-inflammatory activity, and drug release profile. Then, the healing function of FOE-CHNPs/calcium alginate hydrogel was compared with a marketed wound care product in a rat model of diabetic wound. In vitro study showed that the hydrogel system promoted skin cells viability and migration. In vivo wound healing assay showed that the animals treated with the FOE-CHNPs/calcium alginate hydrogel had comparable wound healing potential with the GranuGEL® as the marketed wound care hydrogel. Gene expression studies showed that FOE-CHNPs/calcium alginate hydrogel upregulated the tissue expression levels of collagen type 1, collagen type 2, VEGF, b-FGF and TGF-B genes. This preclinical research, suggests potential use of FOE-loaded calcium alginate hydrogel system in treating diabetic wounds in the clinic.

摘要

糖尿病伤口若不治疗可能会变成慢性伤口。在当前研究中，通过将负载紫堇提取物的壳聚糖纳米颗粒（FOE-CHNPs）掺入海藻酸钙水凝胶中，开发出了一种潜在的伤口敷料。对所制备的水凝胶的微观结构、细胞毒性、细胞迁移活性、细胞保护潜力、孔隙率、体外抗炎活性和药物释放曲线进行了评估。然后，在糖尿病伤口大鼠模型中，将FOE-CHNPs/海藻酸钙水凝胶的愈合功能与一种市售伤口护理产品进行了比较。体外研究表明，该水凝胶系统可促进皮肤细胞的活力和迁移。体内伤口愈合试验表明，用FOE-CHNPs/海藻酸钙水凝胶治疗的动物与作为市售伤口护理水凝胶的GranuGEL®具有相当的伤口愈合潜力。基因表达研究表明，FOE-CHNPs/海藻酸钙水凝胶上调了I型胶原蛋白、II型胶原蛋白、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（b-FGF）和转化生长因子-β（TGF-B）基因的组织表达水平。这项临床前研究表明，负载FOE的海藻酸钙水凝胶系统在临床上治疗糖尿病伤口具有潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/8329d03347ca/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/0b95f0f65b82/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/db58a949442d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/1de3e5fa3c59/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/30c7ed02be6c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/a5079f6a39e2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/398a2ec2ebd5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/ad30abc2ca94/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/b0786155904e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/1eee633232e0/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/3be2d0456e69/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/8329d03347ca/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/0b95f0f65b82/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/db58a949442d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/1de3e5fa3c59/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/30c7ed02be6c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/a5079f6a39e2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/398a2ec2ebd5/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/ad30abc2ca94/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/b0786155904e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/1eee633232e0/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/3be2d0456e69/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17ad/10372204/8329d03347ca/gr10.jpg

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