Wang Ying, Vizely Katrina, Li Chen Yu, Shen Karen, Shakeri Amid, Khosravi Ramak, Smith James Ryan, Alteza Eugene Alfonzo I I, Zhao Yimu, Radisic Milica
Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.
Toronto General Research Institute, University Health Network, Toronto, ON M5G 2C4 Canada.
Regen Biomater. 2024 Mar 27;11:rbae032. doi: 10.1093/rb/rbae032. eCollection 2024.
The substantial economic impact of non-healing wounds, scarring, and burns stemming from skin injuries is evident, resulting in a financial burden on both patients and the healthcare system. This review paper provides an overview of the skin's vital role in guarding against various environmental challenges as the body's largest protective organ and associated developments in biomaterials for wound healing. We first introduce the composition of skin tissue and the intricate processes of wound healing, with special attention to the crucial role of immunomodulation in both acute and chronic wounds. This highlights how the imbalance in the immune response, particularly in chronic wounds associated with underlying health conditions such as diabetes and immunosuppression, hinders normal healing stages. Then, this review distinguishes between traditional wound-healing strategies that create an optimal microenvironment and recent peptide-based biomaterials that modulate cellular processes and immune responses to facilitate wound closure. Additionally, we highlight the importance of considering the stages of wounds in the healing process. By integrating advanced materials engineering with an in-depth understanding of wound biology, this approach holds promise for reshaping the field of wound management and ultimately offering improved outcomes for patients with acute and chronic wounds.
皮肤损伤导致的不愈合伤口、瘢痕形成和烧伤所产生的巨大经济影响是显而易见的，给患者和医疗系统都带来了经济负担。本文综述了皮肤作为人体最大的保护器官在抵御各种环境挑战中的重要作用，以及伤口愈合生物材料的相关进展。我们首先介绍皮肤组织的组成和伤口愈合的复杂过程，特别关注免疫调节在急性和慢性伤口中的关键作用。这突出了免疫反应失衡，尤其是与糖尿病和免疫抑制等潜在健康状况相关的慢性伤口中的免疫反应失衡，如何阻碍正常愈合阶段。然后，本综述区分了创造最佳微环境的传统伤口愈合策略和调节细胞过程及免疫反应以促进伤口闭合的新型肽基生物材料。此外，我们强调了在愈合过程中考虑伤口阶段的重要性。通过将先进的材料工程与对伤口生物学的深入理解相结合，这种方法有望重塑伤口管理领域，并最终为急性和慢性伤口患者提供更好的治疗效果。
