Hossain Md Jamal, Jabin Nasrin, Ahmmed Foyez, Sultana Arifa, Abdur Rahman S M, Islam Md Rabiul
Department of Pharmacy State University of Bangladesh Dhaka Bangladesh.
Department of Peace and Conflict Studies University of Dhaka Dhaka Bangladesh.
Health Sci Rep. 2023 Jul 28;6(8):e1465. doi: 10.1002/hsr2.1465. eCollection 2023 Aug.
Irrational antibiotic (AB) usage poses a serious concern to third-world countries because of poor surveillance, lack of information, and patients' propensity for self-medication. Additionally, the unpredictability of the coronavirus disease 2019 (COVID-19) pandemic promoted the abuse of ABs, which accelerated the prevalence of antibiotic resistance (ABR). The primary aim of this study was to assess the pattern of AB usage and irrational use of ABs-related potential factors associated with ABR among the students and teachers of a leading public university of Bangladesh.
A cross-sectional web-based survey was conducted among the students and teachers ( = 783) of the selected university, from January 1 to February 28, 2022. Descriptive statistics, test, and logistic regression analysis were employed to analyze the collected data.
The regression analysis supported that male participants had a 34% lower experience of acquiring ABR than female respondents (adjusted odds ratio [AOR] = 0.66, 95% confidence interval [CI] = 0.448, 0.973; = 0.036). The 1st/2nd-year level students had more than two times higher experience with ABR than the master's or higher-class students (AOR = 2.149, 95% CI = 1.047, 4.412; = 0.037). The participants who took ABs for 4-6 days showed more than two times ABR experience than those who took ABs for above 10 days (AOR = 2.016, 95% CI = 1.016, 4.003; = 0.045). Respondents who finished their AB medication (dose completion) had a 57% less chance of acquiring ABR than the participants who did not complete their dose.
This study found that irrational use of ABs is more prevalent among the youth and female participants. At this stage, there is an urgent need for comprehensive statutory AB control rules, as well as measures for appropriate information, education, and surveillance throughout different groups of Bangladesh.
由于监测不力、信息匮乏以及患者自我用药的倾向，抗生素的不合理使用给第三世界国家带来了严重问题。此外，2019年冠状病毒病（COVID-19）大流行的不可预测性助长了抗生素的滥用，加速了抗生素耐药性（ABR）的流行。本研究的主要目的是评估孟加拉国一所顶尖公立大学的学生和教师中抗生素的使用模式以及与ABR相关的抗生素不合理使用潜在因素。
于2022年1月1日至2月28日对所选大学的学生和教师（n = 783）进行了一项基于网络的横断面调查。采用描述性统计、检验和逻辑回归分析来分析收集到的数据。
回归分析表明，男性参与者获得ABR的经历比女性受访者低34%（调整优势比[AOR] = 0.66，95%置信区间[CI] = 0.448，0.973；P = 0.036）。本科一、二年级学生获得ABR的经历是硕士及以上年级学生的两倍多（AOR = 2.149，95% CI = 1.047，4.412；P = 0.037）。服用抗生素4 - 6天的参与者获得ABR的经历是服用抗生素超过10天者的两倍多（AOR = 2.016，95% CI = 1.016，4.003；P = 0.045）。完成抗生素疗程（剂量服完）的受访者获得ABR的几率比未完成剂量的参与者低57%。
本研究发现，抗生素的不合理使用在青年和女性参与者中更为普遍。现阶段，迫切需要全面的法定抗生素控制规则，以及在孟加拉国不同群体中进行适当信息、教育和监测的措施。
