Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi, 710069, PR China.
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi, 710069, PR China.
Chem Biol Interact. 2015 Oct 5;240:220-38. doi: 10.1016/j.cbi.2015.09.005. Epub 2015 Sep 8.
The application of lipidomics, after genomics, proteomics and metabolomics, offered largely opportunities to illuminate the entire spectrum of lipidome based on a quantitative or semi-quantitative level in a biological system. When combined with advances in proteomics and metabolomics high-throughput platforms, lipidomics provided the opportunity for analyzing the unique roles of specific lipids in complex cellular processes. Abnormal lipid metabolism was demonstrated to be greatly implicated in many human lifestyle-related diseases. In this review, we focused on lipidomic applications in brain injury disease, cancer, metabolic disease, cardiovascular disease, respiratory disease and infectious disease to discover disease biomarkers and illustrate biochemical metabolic pathways. We also discussed the analytical techniques, future perspectives and potential problems of lipidomic applications. The application of lipidomics in disease biomarker discovery provides the opportunity for gaining novel insights into biochemical mechanism.
在基因组学、蛋白质组学和代谢组学之后，脂质组学的应用为在生物系统中基于定量或半定量水平阐明整个脂质组谱提供了很大的机会。当与蛋白质组学和代谢组学高通量平台的进展相结合时，脂质组学为分析特定脂质在复杂细胞过程中的独特作用提供了机会。已经证明，异常的脂质代谢与许多与人类生活方式相关的疾病密切相关。在这篇综述中，我们重点介绍了脂质组学在脑损伤疾病、癌症、代谢疾病、心血管疾病、呼吸疾病和传染病中的应用，以发现疾病生物标志物并阐明生化代谢途径。我们还讨论了脂质组学应用的分析技术、未来展望和潜在问题。脂质组学在疾病生物标志物发现中的应用为深入了解生化机制提供了机会。
