Wood R B, Bogdan G F
Am J Epidemiol. 1986 Oct;124(4):671-7. doi: 10.1093/oxfordjournals.aje.a114440.
Studies have associated insecticides used for spruce budworm control with Reye's syndrome. In Maine, spruce budworm insecticide spraying began in 1954, and an annual spray program was started in 1972. Reye's syndrome incidence information (1978-1982), obtained from hospital discharge data, death certificates, and reports to the Bureau of Health, was compared with the geographic distribution of spruce budworm insecticide spraying. No association between Reye's syndrome and spruce budworm spraying was found, although some geographic clustering of Reye's syndrome cases was observed.
研究表明，用于防治云杉芽虫的杀虫剂与瑞氏综合征有关。在缅因州，1954年开始喷洒防治云杉芽虫的杀虫剂，1972年启动了年度喷洒计划。从医院出院数据、死亡证明以及向卫生局提交的报告中获取了1978 - 1982年瑞氏综合征的发病信息，并与云杉芽虫杀虫剂喷洒的地理分布进行了比较。尽管观察到瑞氏综合征病例存在一些地理聚集现象，但未发现瑞氏综合征与云杉芽虫喷洒之间存在关联。
