Corey L, Rubin R J, Thompson T R, Noble G R, Cassidy E, Hattwick M A, Gregg M B, Eddins D
J Infect Dis. 1977 Mar;135(3):398-407. doi: 10.1093/infdis/135.3.398.
Prospective surveillance for Reye's syndrome in Michigan revealed the occurrence of 46 cases between December 15, 1973 and June 1, 1974. In an attempt to determine the incidence of influenza B-associated Reye's syndrome, a randomized point-prevalence survey of 1,041 schoolchildren was done in a county in Michigan where there had been simultaneous outbreaks of influenza B and Reye's syndrome. Of the children tested, 20% had titers of hemagglutination-inhibiting antibody to influenza virus B/Hong Kong/5/72 of greater than or equal 1:20. Based upon this countywide survey, the incidence of Reye's syndrome following influenza B was estimated as between 30.8 and 57.8 cases of Reye's syndrome per 100,000 cases of influenza B. A detailed epidemiologic investigation of the patients who developed Reye's syndrome indicated that the syndrome occurred four times more frequently in children living in rural areas than in children in the urban areas of the state. These studies indicate that, in addition to antecedent viral infections such as influenza B, factor(s) that are most likely extrinsic or environmental also play a role in the pathogenesis of Reye's syndrome.
密歇根州对瑞氏综合征进行的前瞻性监测显示，在1973年12月15日至1974年6月1日期间共出现46例病例。为了确定与乙型流感相关的瑞氏综合征的发病率，在密歇根州一个同时爆发乙型流感和瑞氏综合征的县，对1041名学童进行了随机现患率调查。在接受检测的儿童中，20%对乙型流感病毒B/香港/5/72的血凝抑制抗体效价大于或等于1:20。根据这项全县范围的调查，乙型流感后瑞氏综合征的发病率估计为每10万例乙型流感中有30.8至57.8例瑞氏综合征。对患瑞氏综合征的患者进行的详细流行病学调查表明，该综合征在农村地区儿童中的发生率是该州城市地区儿童的四倍。这些研究表明，除了如乙型流感等先前的病毒感染外，最有可能是外部或环境因素也在瑞氏综合征的发病机制中起作用。
