Aoyama Takahiro, Shimizu Hidetoshi, Koide Yutaro, Kitagawa Tomoki, Tachibana Hiroyuki, Suzuki Kojiro, Kodaira Takeshi
Department of Radiation Oncology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-Ku, Nagoya, Aichi 464-8681, Japan.
Department of Radiology, Aichi Medical University, 1-1 Yazako-karimata, Nagakute, Aichi 480-1195 Japan.
Phys Imaging Radiat Oncol. 2023 Jul 5;27:100468. doi: 10.1016/j.phro.2023.100468. eCollection 2023 Jul.
We investigated the risk of secondary cancers in rectum and bladder for prostate cancer radiotherapy using a feasibility assessment tool. We calculated the risk of secondary cancer by generating a dose-volume histogram based on an ideal dose falloff function (f-value). This study found a smaller f-value was associated with a lower secondary cancer risk in the rectum but a higher risk in the bladder. The study suggests setting the f-value at 0-0.1 as the optimization goal for the rectum and 0.4 for the bladder is reasonable and feasible for reducing the risk of secondary cancer and other adverse events.
我们使用一种可行性评估工具，研究了前列腺癌放疗后直肠和膀胱发生继发性癌症的风险。我们通过基于理想剂量衰减函数（f值）生成剂量体积直方图来计算继发性癌症的风险。本研究发现，较小的f值与直肠较低的继发性癌症风险相关，但与膀胱较高的风险相关。该研究表明，将直肠的f值设定为0 - 0.1、膀胱的f值设定为0.4作为优化目标，对于降低继发性癌症和其他不良事件的风险是合理且可行的。
