利用可行性剂量体积直方图评估前列腺癌放疗后直肠和膀胱发生继发性癌症的风险。
Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose-volume histogram.
作者信息
Aoyama Takahiro, Shimizu Hidetoshi, Koide Yutaro, Kitagawa Tomoki, Tachibana Hiroyuki, Suzuki Kojiro, Kodaira Takeshi
机构信息
Department of Radiation Oncology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-Ku, Nagoya, Aichi 464-8681, Japan.
Department of Radiology, Aichi Medical University, 1-1 Yazako-karimata, Nagakute, Aichi 480-1195 Japan.
出版信息
Phys Imaging Radiat Oncol. 2023 Jul 5;27:100468. doi: 10.1016/j.phro.2023.100468. eCollection 2023 Jul.
We investigated the risk of secondary cancers in rectum and bladder for prostate cancer radiotherapy using a feasibility assessment tool. We calculated the risk of secondary cancer by generating a dose-volume histogram based on an ideal dose falloff function (f-value). This study found a smaller f-value was associated with a lower secondary cancer risk in the rectum but a higher risk in the bladder. The study suggests setting the f-value at 0-0.1 as the optimization goal for the rectum and 0.4 for the bladder is reasonable and feasible for reducing the risk of secondary cancer and other adverse events.
我们使用一种可行性评估工具，研究了前列腺癌放疗后直肠和膀胱发生继发性癌症的风险。我们通过基于理想剂量衰减函数（f值）生成剂量体积直方图来计算继发性癌症的风险。本研究发现，较小的f值与直肠较低的继发性癌症风险相关，但与膀胱较高的风险相关。该研究表明，将直肠的f值设定为0 - 0.1、膀胱的f值设定为0.4作为优化目标，对于降低继发性癌症和其他不良事件的风险是合理且可行的。
Zotero 插件