异腈通过N≡C键断裂发生意外的反应性转变：对称磺酰胍的级联形成。

Mishra Debashish, Rajkhowa Sagarika, Phukan Prodeep

Department of Chemistry, Gauhati University, Guwahati, Assam 781014, India.

iScience. 2023 Jul 3;26(8):107258. doi: 10.1016/j.isci.2023.107258. eCollection 2023 Aug 18.

Unanticipated formation of symmetrical sulfonyl guanidine was observed while treating isonitriles with -dibromoarylsulfonamides in absence of an external amine source. Interesting feature of this work is that one molecule of isonitrile initially reacts with dibromoarylsulfonamide via the C-end to produce the intermediate carbodiimide while the other molecule undergoes C≡N triple bond cleavage to react as amine source with the intermediate. This switch of reactivity from C-center to N-center of the isonitrile generated symmetrical guanidine.

在没有外部胺源的情况下，用二溴芳基磺酰胺处理异腈时，观察到意外形成了对称的磺酰胍。这项工作的有趣之处在于，一个异腈分子最初通过C端与二溴芳基磺酰胺反应生成中间体碳二亚胺，而另一个分子发生C≡N三键断裂，作为胺源与中间体反应。异腈从C中心到N中心的这种反应性转变生成了对称胍。