Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, People's Republic of China.
Graduate School, Wannan Medical College, Wuhu, AnHui, 241002, People's Republic of China.
Drug Des Devel Ther. 2023 Jul 25;17:2165-2181. doi: 10.2147/DDDT.S415659. eCollection 2023.
Mesenchymal stem cell-derived exosomes (MSC-exosomes) have been found to effectively improve the systemic inflammatory response caused by acute lung injury and acute respiratory distress syndrome (ALI/ARDS), regulate systemic immune disorders, and help injured cells repair. The purpose of this study was to take a holistic view of the current status and trends of MSC-exosomes research in ALI/ARDS.
Bibliometrix, Citespace and VOSviewer software were used for bibliometric analysis of the data. We analysed the world trends, country distribution, institution contribution, most relevant journals and authors, research hotspots, and research hotspots related to Coronavirus Disease 2019 (COVID-19) based on the data collected.
China possessed the largest number of publications, while the USA had the highest H-index and the number of citations. Both China and the USA had a high influence in this research field. The largest number of publications in the field of MSC-exosomes and ALI/ARDS were mainly from the University of California system. Stem Cell Research & Therapy published the largest number of papers in this scope. The author with the greatest contribution was LEE JW, and ZHU YG published an article in Stem Cell with the highest local citation score. The most frequent keyword and the latest research hotspot were "NF-κB" and "Coronavirus Disease 2019". Furthermore, our bibliometric analysis results demonstrated that MSC-exosomes intervention and treatment can effectively alleviate the inflammatory response caused by ALI/ARDS.
Our bibliometric study suggested the USA and China have a strong influence in this field. COVID-19-induced ALI/ARDS had become a hot topic of research.
间充质干细胞衍生的外泌体（MSC-exosomes）已被发现可有效改善急性肺损伤和急性呼吸窘迫综合征（ALI/ARDS）引起的全身炎症反应，调节全身免疫紊乱，帮助受损细胞修复。本研究旨在全面了解 MSC-exosomes 在 ALI/ARDS 中的研究现状和趋势。
采用 bibliometrix、Citespace 和 VOSviewer 软件对数据进行文献计量学分析。我们根据收集到的数据，分析了世界趋势、国家分布、机构贡献、最相关的期刊和作者、研究热点以及与 2019 年冠状病毒病（COVID-19）相关的研究热点。
中国的发文量最大，而美国的 H 指数和被引次数最高。中美两国在该研究领域均具有较高的影响力。MSC-exosomes 和 ALI/ARDS 领域发文量最大的机构主要来自加利福尼亚大学系统。《干细胞研究与治疗》在该领域发表的论文最多。贡献最大的作者是 LEE JW，而 ZHU YG 在《干细胞》上发表的一篇文章的本地引文得分最高。最频繁的关键词和最新的研究热点是“NF-κB”和“2019 年冠状病毒病”。此外，我们的文献计量分析结果表明，MSC-exosomes 的干预和治疗可有效减轻 ALI/ARDS 引起的炎症反应。
我们的文献计量研究表明，美国和中国在该领域具有较强的影响力。COVID-19 引起的 ALI/ARDS 已成为研究热点。
