Huang Enyao, Gao Li, Yu Ruiyu, Xu Keying, Wang Lihong
Department of Pathophysiology, Medical College of Southeast University, Nanjing, 210009, China.
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Nanjing, 210009, China.
Heliyon. 2023 Sep 1;9(9):e19759. doi: 10.1016/j.heliyon.2023.e19759. eCollection 2023 Sep.
Acute lung injury (ALI) is a prevalent critical disorder that disrupts the body's homeostasis in patients. The progression from ALI to acute respiratory distress syndrome (ARDS) is often accompanied by programmed cell death (PCD). However, there has been a lack of systematic research and comprehensive analysis on the role of different types of PCD in ALI/ARDS. This study aims to analyze the research status, trends, research hotspots, and compare the contribution of publications from different countries, institutions, journals and authors in the field of PCD in ALI/ARDS using bibliometric analysis. We collected publications regard to PCD and ALI/ARDS from Web of Science during 2000-2022. VOSviewer, Citespace, Scimago Graphica, Pajek, and GraphPad Prism 9.0 software were used for further analyzed and visualized. We identified a total of 3495 publications. The number of publications has increased since the beginning of the new century. China produced the most publications (1965), while the United States ranks first in the number of citations (40141). Shanghai Jiao Tong University and American Journal of Physiology-Lung Cellular and Molecular Physiology were the most prolific institution and journal, respectively. Wang, Ping has published most papers (23) while publications from Lee, Pj have most citations (2016). In terms of keywords, "apoptosis" and "inflammation" are the most frequently occurring, but there has been a recent shift from "apoptosis" and "autophagy" to "necroptosis", "pyroptosis", and "ferroptosis". Additionally, COVID-19 and long noncoding RNA (lncRNA) have become research hotspots in recent years. In conclusion, this bibliometric analysis reveals the research directions and frontier hotspots of PCD in ALI/ARDS. China and the United States have made important contributions to the development of this field. The research hotspots have recently focused on necroptosis, pyroptosis, ferroptosiss, COVID-19 and lncRNA.
急性肺损伤（ALI）是一种常见的危重症，会破坏患者体内的稳态。从ALI进展为急性呼吸窘迫综合征（ARDS）通常伴随着程序性细胞死亡（PCD）。然而，对于不同类型的PCD在ALI/ARDS中的作用，一直缺乏系统的研究和全面的分析。本研究旨在通过文献计量分析，分析PCD在ALI/ARDS领域的研究现状、趋势、研究热点，并比较不同国家、机构、期刊和作者的出版物贡献。我们从2000年至2022年期间的Web of Science中收集了关于PCD和ALI/ARDS的出版物。使用VOSviewer、Citespace、Scimago Graphica、Pajek和GraphPad Prism 9.0软件进行进一步分析和可视化。我们共确定了3495篇出版物。自新世纪初以来，出版物数量有所增加。中国发表的出版物最多（1965篇），而美国的被引次数排名第一（40141次）。上海交通大学和《美国生理学杂志 - 肺细胞与分子生理学》分别是发文量最多的机构和期刊。王平发表的论文最多（23篇），而Pj Lee发表的论文被引次数最多（2016次）。在关键词方面，“细胞凋亡”和“炎症”出现频率最高，但最近出现了从“细胞凋亡”和“自噬”向“坏死性凋亡”、“焦亡”和“铁死亡”的转变。此外，COVID - 19和长链非编码RNA（lncRNA）近年来已成为研究热点。总之，这项文献计量分析揭示了PCD在ALI/ARDS中的研究方向和前沿热点。中国和美国对该领域的发展做出了重要贡献。最近的研究热点集中在坏死性凋亡、焦亡、铁死亡、COVID - 19和lncRNA上。
