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一例罕见的合并横纹肌肉瘤异源性成分的小细胞肺癌，通过支气管内超声（EBUS）引导下活检确诊。

A rare case of combined small cell lung carcinoma with heterologous component of rhabdomyosarcoma diagnosed by endobronchial ultrasound (EBUS)-guided biopsy.

作者信息

Cedano Diego, Cedano Jorge, Fels Elliott Daffolyn Rachael, Assi Jasmeet, Madan Rashna, Hyter Stephen, Pitts Lucas R, Postigo Jasahui Maykol R

机构信息

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center, Kansas City, KS, USA.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.

出版信息

Respir Med Case Rep. 2023 Jul 20;45:101899. doi: 10.1016/j.rmcr.2023.101899. eCollection 2023.

DOI:10.1016/j.rmcr.2023.101899
PMID:37521129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10382325/
Abstract

We describe an unusual case of combined small cell lung carcinoma (SCLC) with a heterologous sarcomatous component of rhabdomyosarcoma in a 61-year-old male smoker. The diagnosis was made using endobronchial ultrasound (EBUS)-guided fine needle aspiration and biopsy. This report highlights the challenges of diagnosing small round blue cell tumors in limited material and the importance of ancillary testing. The histologic diagnosis informed clinical management and therapy.

摘要

我们描述了一例罕见病例，一名61岁男性吸烟者患有合并横纹肌肉瘤异源性肉瘤成分的小细胞肺癌（SCLC）。诊断通过支气管内超声（EBUS）引导下细针穿刺抽吸和活检做出。本报告强调了在有限材料中诊断小圆形蓝细胞肿瘤的挑战以及辅助检测的重要性。组织学诊断为临床管理和治疗提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c676/10382325/55e9108c038d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c676/10382325/f207455e9c28/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c676/10382325/e8c1937daeb1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c676/10382325/55e9108c038d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c676/10382325/f207455e9c28/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c676/10382325/e8c1937daeb1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c676/10382325/55e9108c038d/gr3.jpg

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本文引用的文献

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Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.小细胞肺癌临床实践指南（2022 年版），NCCN 肿瘤学临床实践指南
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Combined small-cell lung carcinoma.小细胞肺癌合并症
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A resected case of combined small cell lung carcinoma with carcinosarcoma.一例小细胞肺癌合并癌肉瘤的切除病例。
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Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.综合性基因组分析鉴定出小细胞肺癌的重要体细胞驱动突变。
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Genomic and clinical analysis of fusion gene amplification in rhabdomyosarcoma: a report from the Children's Oncology Group.横纹肌肉瘤中融合基因扩增的基因组和临床分析：来自儿童肿瘤协作组的报告。
Genes Chromosomes Cancer. 2012 Jul;51(7):662-74. doi: 10.1002/gcc.21953. Epub 2012 Mar 23.
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Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas.小细胞癌及其与鳞状细胞癌和其他非小细胞癌的鉴别诊断的最新进展。
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Primary pulmonary rhabdomyosarcoma in an adult with neurofibromatosis-1.一名患有神经纤维瘤病1型的成年患者的原发性肺横纹肌肉瘤
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