Gao Lin, Mu Xiuying, Jiao Yan-Mei, Wang Fu-Sheng
Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
Peking University 302 Clinical Medical School, Beijing 100039, China.
Infect Dis Immun. 2021 Nov 3;2(1):29-33. doi: 10.1097/ID9.0000000000000027. eCollection 2022 Jan.
The pandemic of coronavirus disease 2019 has threatened humans for more than one and a half years. In particular, viral mutation like delta strain has led to third- or fourth-wave transmission among the countries in Asia, Europe, and North America. Although large-scale vaccination has been carried out in many countries, the incidence of reinfection and vaccine-past breakthrough infection is becoming an emerging challenge to humans worldwide. The related mechanisms underlying the reinfection and breakthrough infection remain unknown. In this review, we summarized the challenge and related reasons for severe acute respiratory syndrome coronavirus 2 reinfection and breakthrough infection. Simultaneously, we addressed some critical contents of the study in future.
2019年冠状病毒病大流行已威胁人类超过一年半。特别是，像德尔塔毒株这样的病毒变异导致了亚洲、欧洲和北美的国家出现第三波或第四波传播。尽管许多国家已大规模开展疫苗接种，但再次感染和疫苗突破性感染的发生率正成为全球人类面临的新挑战。再次感染和突破性感染的相关机制仍不清楚。在本综述中，我们总结了严重急性呼吸综合征冠状病毒2再次感染和突破性感染的挑战及相关原因。同时，我们也探讨了未来研究的一些关键内容。
