Bergwell Hannah, Trevarrow Michael P, Heinrichs-Graham Elizabeth, Reelfs Anna, Ott Lauren R, Penhale Samantha H, Wilson Tony W, Kurz Max J
Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United States.
Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, United States.
Front Neurol. 2023 Jul 13;14:1163964. doi: 10.3389/fneur.2023.1163964. eCollection 2023.
Cerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underlying neurophysiological mechanisms remain poorly understood.
We began to address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging to study how the amplitude of spontaneous cortical activity (i.e., resting state) is altered during this transition period in a cohort of 38 individuals with spastic diplegic CP (Age range = 9.80-47.50 years, 20 females) and 67 neurotypical controls (NT) (Age range = 9.08-49.40 years, Females = 27). MEG data from a five-minute eyes closed resting-state paradigm were source imaged, and the power within the delta (2-4 Hz), theta (5-7 Hz), alpha (8-12 Hz), beta (15-29 Hz), and gamma (30-59 Hz) frequency bands were computed.
For both groups, the delta and theta spontaneous power decreased in the bilateral temporoparietal and superior parietal regions with age, while alpha, beta, and gamma band spontaneous power increased in temporoparietal, frontoparietal and premotor regions with age. We also found a significant group x age interaction, such that participants with CP demonstrated significantly less age-related increases in the spontaneous beta activity in the bilateral sensorimotor cortices compared to NT controls.
Overall, these results demonstrate that the spontaneous neural activity in individuals with CP has an altered trajectory when transitioning from adolescents to adulthood. We suggest that these differences in spontaneous cortical activity may play a critical role in the aberrant motor actions seen in this patient group, and may provide a neurophysiological marker for assessing the effectiveness of current treatment strategies that are directed at improving the mobility and sensorimotor impairments seen in individuals with CP.
脑瘫（CP）是最常见的神经发育性运动障碍，会导致终身的感觉、感知和运动障碍。此外，随着脑瘫患者从青少年过渡到成年，这些障碍似乎会急剧恶化，尽管其潜在的神经生理机制仍知之甚少。
我们通过利用脑磁图（MEG）脑成像来研究38名痉挛性双侧瘫脑瘫患者（年龄范围=9.80 - 47.50岁，20名女性）和67名神经典型对照者（NT）（年龄范围=9.08 - 49.40岁，女性=27名）在这一过渡时期自发皮质活动（即静息状态）的振幅是如何变化的，从而开始填补这一知识空白。对来自5分钟闭眼静息状态范式的MEG数据进行源成像，并计算δ（2 - 4Hz）、θ（5 - 7Hz）、α（8 - 12Hz）、β（15 - 29Hz）和γ（30 - 59Hz）频段内的功率。
对于两组而言，双侧颞顶叶和顶上叶区域的δ和θ自发功率随年龄下降，而颞顶叶、额顶叶和运动前区的α、β和γ频段自发功率随年龄增加。我们还发现了显著的组×年龄交互作用，即与NT对照者相比，脑瘫患者在双侧感觉运动皮层中与年龄相关的自发β活动增加明显较少。
总体而言，这些结果表明，脑瘫患者从青少年过渡到成年时，其自发神经活动轨迹发生了改变。我们认为，自发皮质活动的这些差异可能在该患者群体中出现的异常运动行为中起关键作用，并可能为评估当前旨在改善脑瘫患者运动能力和感觉运动障碍的治疗策略的有效性提供一种神经生理标志物。
