Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE 68010.
College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198.
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2212776120. doi: 10.1073/pnas.2212776120. Epub 2023 Jan 18.
In the largest and most expansive lifespan magnetoencephalography (MEG) study to date (n = 434, 6 to 84 y), we provide critical data on the normative trajectory of resting-state spontaneous activity and its temporal dynamics. We perform cutting-edge analyses to examine age and sex effects on whole-brain, spatially-resolved relative and absolute power maps, and find significant age effects in all spectral bands in both types of maps. Specifically, lower frequencies showed a negative correlation with age, while higher frequencies positively correlated with age. These correlations were further probed with hierarchical regressions, which revealed significant nonlinear trajectories in key brain regions. Sex effects were found in absolute but not relative power maps, highlighting key differences between outcome indices that are generally used interchangeably. Our rigorous and innovative approach provides multispectral maps indicating the unique trajectory of spontaneous neural activity across the lifespan, and illuminates key methodological considerations with the widely used relative/absolute power maps of spontaneous cortical dynamics.
在迄今为止最大和最广泛的寿命期磁共振脑磁图（MEG）研究中（n = 434，6 至 84 岁），我们提供了关于静息状态自发活动及其时间动态的规范轨迹的关键数据。我们进行了前沿分析，以检查全脑、空间分辨的相对和绝对功率图的年龄和性别效应，并在两种类型的图谱中均发现所有谱带的显著年龄效应。具体而言，低频与年龄呈负相关，而高频与年龄呈正相关。这些相关性进一步通过分层回归进行了探究，揭示了关键脑区的显著非线性轨迹。仅在绝对功率图中发现了性别效应，而不是在相对功率图中，这突出了通常可互换使用的结果指标之间的关键差异。我们严格而创新的方法提供了多谱图，表明了整个寿命期内自发神经活动的独特轨迹，并阐明了广泛使用的自发皮质动力学的相对/绝对功率图的关键方法学考虑因素。
