Busboom Morgan, Corr Brad, Reelfs Anna, Trevarrow Mike, Reelfs Heidi, Baker Sarah, Bergwell Hannah, Wilson Tony W, Moreau Noelle G, Kurz Max J
Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, Nebraska.
Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska.
Arch Rehabil Res Clin Transl. 2022 Jan 25;4(1):100180. doi: 10.1016/j.arrct.2022.100180. eCollection 2022 Mar.
To utilize magnetoencephalographic (MEG) brain imaging to examine potential changes in sensorimotor cortical oscillations after therapeutic power training in individuals with cerebral palsy (CP).
Cohort.
Academic medical center.
Individuals with CP (N=11; age=15.9±1.1 years; Gross Motor Function Classification System I- III) and neurotypical controls (NTs; N=16; age=14.6±0.8 years).
Participants with CP underwent 24 (8 weeks; 3 days a week) sessions of high-velocity lower extremity power training on a leg press. The NTs underwent single baseline MEG assessments.
Pre-post bilateral leg press 1-repetition maximum and peak power production were used to assess the muscular performance changes. The 10-m walk and 1-minute walk tests were used to assess mobility changes. During MEG recordings, participants used their right leg to complete a goal-directed isometric target-matching task. Advanced beamforming methods were subsequently used to image the strength of the sensorimotor beta oscillatory power.
Before the therapeutic power training, the participants with CP had stronger beta sensorimotor cortical oscillations compared with the NT controls. However, the beta sensorimotor cortical oscillations were weaker and approximated the controls after the participants with CP completed the therapeutic power training protocol. There also was a link between the amount of improvement in leg peak power production and the amount of reduction in sensorimotor cortical oscillations seen after therapy.
Therapeutic power training appears to optimize the sensorimotor cortical oscillations of individuals with CP, and these neuroplastic changes partly contribute to improvements in the leg peak power production of individuals with CP. Therapeutic power training might provide the key ingredients for beneficial neuroplastic change.
利用脑磁图（MEG）脑成像技术，检查脑瘫（CP）患者在进行治疗性力量训练后感觉运动皮层振荡的潜在变化。
队列研究。
学术医疗中心。
CP患者（N = 11；年龄 = 15.9±1.1岁；粗大运动功能分类系统I - III级）和神经典型对照者（NTs；N = 16；年龄 = 14.6±0.8岁）。
CP患者在腿举训练器上进行24次（8周；每周3天）的高速下肢力量训练。NTs进行单次基线MEG评估。
训练前后双侧腿举1次重复最大值和峰值功率输出用于评估肌肉性能变化。10米步行和1分钟步行测试用于评估运动能力变化。在MEG记录期间，参与者用右腿完成一个目标导向的等长目标匹配任务。随后使用先进的波束形成方法对感觉运动β振荡功率的强度进行成像。
在治疗性力量训练前，CP患者的β感觉运动皮层振荡比NTs对照组更强。然而，CP患者完成治疗性力量训练方案后，β感觉运动皮层振荡变弱且接近对照组。治疗后腿部峰值功率输出的改善量与感觉运动皮层振荡减少量之间也存在关联。
治疗性力量训练似乎优化了CP患者的感觉运动皮层振荡，这些神经可塑性变化部分有助于改善CP患者的腿部峰值功率输出。治疗性力量训练可能为有益的神经可塑性变化提供关键因素。
