De Beukelaer Sophie, Sokolov A A, Müri R M
Department of Neurology, University Hospital, Inselspital Bern, Bern, Switzerland.
Service de Neuropsychologie et de Neuroréhabilitation, Département des Neurosciences Cliniques, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Front Neurol. 2023 Jul 13;14:1183265. doi: 10.3389/fneur.2023.1183265. eCollection 2023.
Odors evoking vivid and intensely felt autobiographical memories are known as the "Proust phenomenon," delineating the particularity of olfaction in being more effective with eliciting emotional memories than other sensory modalities. The phenomenon has been described extensively in healthy participants as well as in patients during pre-epilepsy surgery evaluation after focal stimulation of the amygdalae and post-traumatic stress disorder (PTSD). In this study, we provide the inaugural description of aversive odor-evoked autobiographical memories after stroke in the right hippocampal, parahippocampal, and thalamic nuclei. As potential underlying neural signatures of the phenomenon, we discuss the disinhibition of limbic circuits and impaired communication between the major networks, such as saliency, central executive, and default mode network.
唤起生动且强烈的自传体记忆的气味被称为“普鲁斯特现象”，它描绘了嗅觉的特殊性，即与其他感官模态相比，嗅觉在引发情感记忆方面更有效。该现象在健康参与者以及在癫痫手术前评估期间接受杏仁核局部刺激后的患者和创伤后应激障碍（PTSD）患者中都有广泛描述。在本研究中，我们首次描述了右侧海马体、海马旁回和丘脑核中风后厌恶气味诱发的自传体记忆。作为该现象潜在的神经特征，我们讨论了边缘回路的去抑制以及主要网络（如显著性、中央执行和默认模式网络）之间的通信受损。
