微小RNA靶向作用：卵巢癌的一种新型治疗干预手段

Asl Elmira Roshani, Sarabandi Sajed, Shademan Behrouz, Dalvandi Kourosh, Sheikhansari Golshan, Nourazarian Alireza

Social Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, Iran.

Department of Veterinary, Faculty of Medicine Sciences, Islamic Azad University of Karaj, Karaj, Iran.

Biochem Biophys Rep. 2023 Jul 24;35:101519. doi: 10.1016/j.bbrep.2023.101519. eCollection 2023 Sep.

Ovarian cancer, a perilous form of cancer affecting the female reproductive system, exhibits intricate communication networks that contribute to its progression. This study aims to identify crucial molecular abnormalities linked to the disease to enhance diagnostic and therapeutic strategies. In particular, we investigate the role of microRNAs (miRNAs) as diagnostic biomarkers and explore their potential in treating ovarian cancer. By targeting miRNAs, which can influence multiple pathways and genes, substantial therapeutic benefits can be attained. In this review we want to shed light on the promising application of miRNA-based interventions and provide insights into the specific miRNAs implicated in ovarian cancer pathogenesis.

卵巢癌是一种影响女性生殖系统的危险癌症，它具有复杂的通讯网络，促进其发展。本研究旨在识别与该疾病相关的关键分子异常，以加强诊断和治疗策略。特别是，我们研究了微小RNA（miRNA）作为诊断生物标志物的作用，并探索它们在治疗卵巢癌方面的潜力。通过靶向可影响多种途径和基因的miRNA，可获得显著的治疗益处。在这篇综述中，我们希望阐明基于miRNA的干预措施的前景应用，并深入了解与卵巢癌发病机制相关的特定miRNA。