Fadel H E, Saad S A, Nelson G H, Davis H C
Am J Obstet Gynecol. 1986 Sep;155(3):544-53. doi: 10.1016/0002-9378(86)90276-0.
Amniotic fluid for fetal lung maturity studies was obtained from 287 healthy and 198 diabetic women. Classes of diabetes were as follows: Class A, 111; Class B, 58; Class C, 13; Class D, 11; Class F, 4; and Class R, 1. The regression lines representing the relationship of amniotic fluid lecithin phosphorus concentration to gestational age at amniocentesis in each of the groups of diabetic patients were not statistically different from those of the control subjects. Each of the diabetic patients was then matched with a control subject of the same race, sex of newborn infant, and gestational age at amniocentesis. The regression lines of the nonhypertensive, hypertensive, and all diabetics were not different from those of their respective matched control subjects. Also there was no difference in the proportion of mature lecithin phosphorus concentrations at different weeks between diabetic and normal women. The absence of a significant influence of diabetes on fetal lung maturation is probably due to improvement in diabetic control resulting in normalization of the fetal metabolic environment.
用于胎儿肺成熟度研究的羊水取自287名健康女性和198名糖尿病女性。糖尿病类型如下：A类，111例；B类，58例；C类，13例；D类，11例；F类，4例；R类，1例。在每组糖尿病患者中，代表羊水卵磷脂磷浓度与羊膜穿刺术时胎龄之间关系的回归线与对照组相比无统计学差异。然后将每位糖尿病患者与一名种族、新生儿性别和羊膜穿刺术时胎龄相同的对照对象进行匹配。非高血压、高血压和所有糖尿病患者的回归线与各自匹配的对照对象的回归线无差异。此外，糖尿病女性和正常女性在不同孕周时成熟卵磷脂磷浓度的比例也没有差异。糖尿病对胎儿肺成熟没有显著影响，可能是由于糖尿病控制的改善导致胎儿代谢环境正常化。
