Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
J Parkinsons Dis. 2023;13(6):893-898. doi: 10.3233/JPD-230049.
Parkinson's disease (PD) most commonly surfaces at middle age. An earlier onset is named early-onset Parkinson's disease (EOPD), but the exact definition is a matter of ongoing scientific debate.
To investigate 40-year EOPD incidence trends in a population-based cohort of parkinsonism in Olmsted County, Minnesota.
We used the Rochester Epidemiology Project (REP) to identify all incident EOPD cases in Olmsted County, 1976-2015. A movement-disorder specialist reviewed all cases to confirm the EOPD diagnosis. For EOPD definition, we used two age cut-offs: motor-symptom onset at or before 50 and 55 years.
EOPD incidence was 1.43/100,000 person-years for ≤55 and 0.55/100,000 for ≤50 years. Men had a higher incidence in both groups [1.84 vs. 1.03 (p = 0.04); and 0.70 vs. 0.40 (p = 0.24), respectively]. EOPD incidence of patients with motor-symptom onset before age 55 increased from 1.02/100.000 person-year 1976-1985, to 1.32/100.000 person-year 2006-2015. A similar trend was observed when ≤50 years cut-off was used (0.28/100,000 person-years 1976-1985, to 0.59/100,000 person-year 2006-2015). However, negative binomial regression found no significant change in incidence per 10 years (RR = 1.04 and 1.24 in the two groups). Incidence was consistently higher in men than women. Median time from EOPD-symptom onset to death was shorter in the EOPD ≤55 group (21.9 years) compared to the EOPD ≤50 group (25.6 years).
We observed an increased trend in the incidence of EOPD with both cut-off ages. Overall, incidence of EOPD was 1.43 (≤55) and 0.55 (≤50) cases per 100,000 person-years, higher in men.
帕金森病（PD）最常见于中年发病。发病年龄较早者称为早发性帕金森病（EOPD），但确切定义仍存在争议。
调查明尼苏达州奥姆斯特德县帕金森病队列中，40 年 EOPD 的发病趋势。
我们使用罗切斯特流行病学项目（REP）确定奥姆斯特德县所有 1976-2015 年的 EOPD 新发病例。一名运动障碍专家对所有病例进行了审查以确认 EOPD 诊断。对于 EOPD 的定义，我们使用了两个年龄截止值：运动症状发病年龄为 50 岁或 55 岁之前。
EOPD 的发病率为≤55 岁的 1.43/100000 人年和≤50 岁的 0.55/100000 人年。两组中男性的发病率均较高[1.84 比 1.03（p=0.04）；0.70 比 0.40（p=0.24）]。EOPD 发病年龄≤55 岁的患者，从 1976-1985 年的 1.02/100000 人年增加到 2006-2015 年的 1.32/100000 人年。当使用≤50 岁的截止值时，也观察到了类似的趋势（1976-1985 年为 0.28/100000 人年，2006-2015 年为 0.59/100000 人年）。然而，负二项式回归未发现每 10 年发病率的显著变化（两组中的 RR 分别为 1.04 和 1.24）。发病率始终高于女性。EOPD 发病年龄≤55 岁的患者（21.9 年）的中位生存时间明显短于 EOPD 发病年龄≤50 岁的患者（25.6 年）。
我们观察到两种截止值的 EOPD 发病率均呈上升趋势。总体而言，EOPD 的发病率为 1.43（≤55 岁）和 0.55（≤50 岁）/100000 人年，男性更高。
