Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Headache. 2023 Sep;63(8):1167-1177. doi: 10.1111/head.14601. Epub 2023 Jul 31.
To present the potential use and relevance of the conditioned pain modulation (CPM) response to migraine diagnosis, outcome prediction, and treatment.
The CPM response is a widely used laboratory test to examine inhibitory pain modulation capabilities.
This narrative review summarizes and synthesizes the findings on the CPM response in patients with migraine.
For diagnosis, we summarized the studies comparing CPM responses between patients with migraine and individuals without migraine or with other headache syndromes, as well as between patients with subtypes of migraine. For prediction, we summarized the studies utilizing the CPM response to predict migraine outcome, such as response to interventions. For treatment, we described a device that utilizes the CPM response for acute and preventative migraine treatment. In addition, we suggest the requirements needed for the CPM response to be used for migraine diagnosis, outcome prediction, and treatment.
Although more research is needed, the CPM response could be a useful tool for improving migraine management.
介绍条件性疼痛调制（CPM）反应在偏头痛诊断、预后预测和治疗中的潜在用途和相关性。
CPM 反应是一种广泛用于检查抑制性疼痛调制能力的实验室测试。
本综述性叙述总结并综合了偏头痛患者 CPM 反应的研究结果。
在诊断方面，我们总结了比较偏头痛患者与无偏头痛或其他头痛综合征患者以及偏头痛不同亚型患者之间 CPM 反应的研究。在预后预测方面，我们总结了利用 CPM 反应预测偏头痛预后的研究，例如对干预措施的反应。在治疗方面，我们描述了一种利用 CPM 反应进行急性和预防性偏头痛治疗的设备。此外，我们还提出了将 CPM 反应用于偏头痛诊断、预后预测和治疗所需的要求。
尽管需要更多的研究，但 CPM 反应可能是改善偏头痛管理的有用工具。
