Bertotti Gabriele, Elizagaray-García Juan Ignacio, Rodríguez-Vico Jaime, Gil-Martínez Alfonso
School of Physiotherapy, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain.
CranioSPain Research Group, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, 28023 Madrid, Spain.
Biomedicines. 2024 Feb 6;12(2):374. doi: 10.3390/biomedicines12020374.
Cluster Headache (CH) is a primary headache that causes severe pain. Some evidence suggests that central mechanisms might be involved. The objective of this study was (1) to compare hyperalgesia signs, temporal summation and conditioned pain modulation among episodic (ECH) and chronic CH (CCH) patients and controls, (2) to compare these factors between sides in the patient groups and (3) to compare the psychophysical variables between the groups. This cross-sectional study included 71 subjects divided into three groups (ECH, CCH and controls). Pressure pain thresholds, temporal summation, conditioned pain modulation and other psychosocial variables were measured. The ANOVA showed differences for all physical outcome measures ( < 0.05). Bonferroni post hoc analyses showed differences when comparing the patient groups with the healthy subjects ( < 0.05), with large effect sizes ( > 0.8). No differences between the patient groups were found for almost all the variables ( > 0.05). Significant differences for all the variables were detected when comparing the symptomatic and non-symptomatic sides in both the ECH and CCH groups ( < 0.05). The ECH and CCH groups showed mechanical hyperalgesia, increased temporal summation and impaired inhibitory mechanisms compared to the controls. Side-to-side differences were also detected within the patient groups. Patients with CCH had poorer sleep quality and quality of life than the controls.
丛集性头痛（CH）是一种导致严重疼痛的原发性头痛。一些证据表明可能涉及中枢机制。本研究的目的是：（1）比较发作性丛集性头痛（ECH）患者、慢性丛集性头痛（CCH）患者和对照组之间的痛觉过敏体征、时间总和以及条件性疼痛调制；（2）比较患者组两侧之间的这些因素；（3）比较各组之间的心理物理学变量。这项横断面研究纳入了71名受试者，分为三组（ECH组、CCH组和对照组）。测量了压力痛阈、时间总和、条件性疼痛调制及其他社会心理变量。方差分析显示所有身体结局指标均存在差异（<0.05）。Bonferroni事后分析显示，将患者组与健康受试者进行比较时存在差异（<0.05），效应量较大（>0.8）。几乎所有变量在患者组之间均未发现差异（>0.05）。在ECH组和CCH组中，比较有症状侧和无症状侧时，所有变量均检测到显著差异（<0.05）。与对照组相比，ECH组和CCH组表现出机械性痛觉过敏、时间总和增加以及抑制机制受损。在患者组内也检测到了两侧之间的差异。CCH患者的睡眠质量和生活质量比对照组差。
